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Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype

Raphael Hesse, Maica Llavero Hurtado, View ORCID ProfileRosemary J. Jackson, Samantha L. Eaton, Abigail G Herrmann, Marti Colom-Cadena, Declan King, Jamie Rose, Jane Tulloch, Chris-Anne McKenzie, Colin Smith, Christopher Henstridge, Douglas Lamont, Thomas M. Wishart, Tara L. Spires-Jones
doi: https://doi.org/10.1101/631556
Raphael Hesse
Centre for Discovery Brain Sciences, UK Dementia Research Institute at the University of Edinburgh
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Maica Llavero Hurtado
The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh
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Rosemary J. Jackson
Centre for Discovery Brain Sciences, UK Dementia Research Institute at the University of Edinburgh
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  • ORCID record for Rosemary J. Jackson
Samantha L. Eaton
The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh
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Abigail G Herrmann
Centre for Discovery Brain Sciences, UK Dementia Research Institute at the University of Edinburgh
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Marti Colom-Cadena
Centre for Discovery Brain Sciences, UK Dementia Research Institute at the University of Edinburgh
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Declan King
Centre for Discovery Brain Sciences, UK Dementia Research Institute at the University of Edinburgh
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Jamie Rose
Centre for Discovery Brain Sciences, UK Dementia Research Institute at the University of Edinburgh
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Jane Tulloch
Centre for Discovery Brain Sciences, UK Dementia Research Institute at the University of Edinburgh
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Chris-Anne McKenzie
Centre for Clinical Brain Sciences, University of Edinburgh
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Colin Smith
Centre for Clinical Brain Sciences, University of Edinburgh
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Christopher Henstridge
Centre for Discovery Brain Sciences, UK Dementia Research Institute at the University of EdinburghUniversity of Dundee, Division of Systems Medicine, Neuroscience, Ninewells Hospital & Medical School, Dundee, UK
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Douglas Lamont
FingerPrints Proteomics Facility, College of Life Sciences, University of Dundee
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Thomas M. Wishart
The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh
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  • For correspondence: Tara.spires-jones@ed.ac.uk T.M.Wishart@ed.ac.uk
Tara L. Spires-Jones
Centre for Discovery Brain Sciences, UK Dementia Research Institute at the University of Edinburgh
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  • For correspondence: Tara.spires-jones@ed.ac.uk T.M.Wishart@ed.ac.uk
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Article Information

doi 
https://doi.org/10.1101/631556
History 
  • May 8, 2019.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Raphael Hesse1,#,
  2. Maica Llavero Hurtado2,#,
  3. Rosemary J. Jackson1,#,
  4. Samantha L. Eaton2,#,
  5. Abigail G Herrmann1,
  6. Marti Colom-Cadena1,
  7. Declan King1,
  8. Jamie Rose1,
  9. Jane Tulloch1,
  10. Chris-Anne McKenzie3,
  11. Colin Smith3,
  12. Christopher Henstridge1,4,
  13. Douglas Lamont5,
  14. Thomas M. Wishart2,* and
  15. Tara L. Spires-Jones1,*
  1. 1Centre for Discovery Brain Sciences, UK Dementia Research Institute at the University of Edinburgh
  2. 2The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh
  3. 3Centre for Clinical Brain Sciences, University of Edinburgh
  4. 4University of Dundee, Division of Systems Medicine, Neuroscience, Ninewells Hospital & Medical School, Dundee, UK
  5. 5FingerPrints Proteomics Facility, College of Life Sciences, University of Dundee
  1. ↵*Corresponding authors (equal contributions) Contact: Tara Spires-Jones, Tara.spires-jones{at}ed.ac.uk, UK Dementia Research Institute, Centre for Discovery Brain Sciences, The University of Edinburgh, 1 George Square, Edinburgh, EH8 9JZ, Scotland, UK, Phone: +44 (0) 131 651 1895, Thomas Wishart T.M.Wishart{at}ed.ac.uk, Royal (Dick) School of Veterinary Studies, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, SCOTLAND, UK
  1. ↵# These authors contributed equally

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Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype
Raphael Hesse, Maica Llavero Hurtado, Rosemary J. Jackson, Samantha L. Eaton, Abigail G Herrmann, Marti Colom-Cadena, Declan King, Jamie Rose, Jane Tulloch, Chris-Anne McKenzie, Colin Smith, Christopher Henstridge, Douglas Lamont, Thomas M. Wishart, Tara L. Spires-Jones
bioRxiv 631556; doi: https://doi.org/10.1101/631556
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Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype
Raphael Hesse, Maica Llavero Hurtado, Rosemary J. Jackson, Samantha L. Eaton, Abigail G Herrmann, Marti Colom-Cadena, Declan King, Jamie Rose, Jane Tulloch, Chris-Anne McKenzie, Colin Smith, Christopher Henstridge, Douglas Lamont, Thomas M. Wishart, Tara L. Spires-Jones
bioRxiv 631556; doi: https://doi.org/10.1101/631556

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