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Fine-scale haplotype structure reveals strong signatures of positive selection in a recombining bacterial pathogen

Brian Arnold, Mashaal Sohail, Crista Wadsworth, Jukka Corander, William P. Hanage, Shamil Sunyaev, Yonatan H. Grad
doi: https://doi.org/10.1101/634147
Brian Arnold
1Division of Informatics, Faculty of Arts and Sciences, Harvard University, Cambridge, MA 02138, USA
2Center for Communicable Disease Dynamics, Harvard T. H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
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  • For correspondence: brianjohnarnold@gmail.com
Mashaal Sohail
3Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA
4Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA
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Crista Wadsworth
5Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
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Jukka Corander
6Department of Biostatistics, University of Oslo, Postboks 1122, Blindern, 0317 Oslo, Norway
7Helsinki Institute for Information Technology HIIT, Department of Computer Science, University of Helsinki, Helsinki, Finland
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William P. Hanage
2Center for Communicable Disease Dynamics, Harvard T. H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
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Shamil Sunyaev
3Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA
4Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA
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Yonatan H. Grad
5Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
8Division of Infectious Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
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Article Information

doi 
https://doi.org/10.1101/634147
History 
  • May 10, 2019.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Brian Arnold1,2,#,
  2. Mashaal Sohail3,4,*,
  3. Crista Wadsworth5,
  4. Jukka Corander6,7,
  5. William P. Hanage2,
  6. Shamil Sunyaev3,4 and
  7. Yonatan H. Grad5,8
  1. 1Division of Informatics, Faculty of Arts and Sciences, Harvard University, Cambridge, MA 02138, USA
  2. 2Center for Communicable Disease Dynamics, Harvard T. H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
  3. 3Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA
  4. 4Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA
  5. 5Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
  6. 6Department of Biostatistics, University of Oslo, Postboks 1122, Blindern, 0317 Oslo, Norway
  7. 7Helsinki Institute for Information Technology HIIT, Department of Computer Science, University of Helsinki, Helsinki, Finland
  8. 8Division of Infectious Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
  1. ↵#Corresponding author: email: brianjohnarnold{at}gmail.com
  • ↵* National Laboratory of Genomics for Biodiversity (UGA-LANGEBIO), CINVESTAV, Irapuato, Guanajuato, Mexico

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Posted May 10, 2019.
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Fine-scale haplotype structure reveals strong signatures of positive selection in a recombining bacterial pathogen
Brian Arnold, Mashaal Sohail, Crista Wadsworth, Jukka Corander, William P. Hanage, Shamil Sunyaev, Yonatan H. Grad
bioRxiv 634147; doi: https://doi.org/10.1101/634147
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Fine-scale haplotype structure reveals strong signatures of positive selection in a recombining bacterial pathogen
Brian Arnold, Mashaal Sohail, Crista Wadsworth, Jukka Corander, William P. Hanage, Shamil Sunyaev, Yonatan H. Grad
bioRxiv 634147; doi: https://doi.org/10.1101/634147

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