Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

VE-PTP participates in vasculogenic mimicry by preventing autophagic degradation of VE-cadherin

Daniel Delgado-Bellido, Concepción Bueno-Galera, Angel Garcia-Diaz, View ORCID ProfileF. Javier Oliver
doi: https://doi.org/10.1101/634584
Daniel Delgado-Bellido
1Instituto de Parasitología y Biomedicina López Neyra, CSIC, CIBERONC, Granada, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Concepción Bueno-Galera
1Instituto de Parasitología y Biomedicina López Neyra, CSIC, CIBERONC, Granada, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Angel Garcia-Diaz
1Instituto de Parasitología y Biomedicina López Neyra, CSIC, CIBERONC, Granada, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
F. Javier Oliver
1Instituto de Parasitología y Biomedicina López Neyra, CSIC, CIBERONC, Granada, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for F. Javier Oliver
  • For correspondence: joliver@ipb.csic.es
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Aberrant extra-vascular expression of VE-cadherin has been observed in metastasis associated with Vasculogenic Mimicry (VM); we have recently shown that in VM prone (VM+) tumor cells VE-cadherin is mainly in the form of pVE-cadherin in Y658 allowing an increased plasticity that potentiates VM development. As excessive VE-cadherin phosphorylation is regulated by the phosphatase VEPTP in endothelial cells in the current study we analysed its role in this aberrant phenotype in malignant tumor cells. We show that human malignant melanoma cells VM+, also express VE-PTP although at lower levels than endothelial cells. The complex VE-PTP/VE-Cadherin/p120-catenin act as a safeguard to prevent VE-cadherin degradation by autophagy. Indeed, silencing of VE-PTP results in complete degradation of VE-cadherin with the features of autophagy and increases the global p120 tyrosine phosphorylation status. In summary, we show that VE-PTP is involved in VM formation and disruption of VE-PTP/VE-Cadherin/p120 complex results in enhanced autophagy in aggressive VM+ cells.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted May 10, 2019.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
VE-PTP participates in vasculogenic mimicry by preventing autophagic degradation of VE-cadherin
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
VE-PTP participates in vasculogenic mimicry by preventing autophagic degradation of VE-cadherin
Daniel Delgado-Bellido, Concepción Bueno-Galera, Angel Garcia-Diaz, F. Javier Oliver
bioRxiv 634584; doi: https://doi.org/10.1101/634584
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
VE-PTP participates in vasculogenic mimicry by preventing autophagic degradation of VE-cadherin
Daniel Delgado-Bellido, Concepción Bueno-Galera, Angel Garcia-Diaz, F. Javier Oliver
bioRxiv 634584; doi: https://doi.org/10.1101/634584

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Cancer Biology
Subject Areas
All Articles
  • Animal Behavior and Cognition (3589)
  • Biochemistry (7553)
  • Bioengineering (5498)
  • Bioinformatics (20742)
  • Biophysics (10304)
  • Cancer Biology (7962)
  • Cell Biology (11624)
  • Clinical Trials (138)
  • Developmental Biology (6595)
  • Ecology (10175)
  • Epidemiology (2065)
  • Evolutionary Biology (13586)
  • Genetics (9525)
  • Genomics (12822)
  • Immunology (7910)
  • Microbiology (19518)
  • Molecular Biology (7647)
  • Neuroscience (42013)
  • Paleontology (307)
  • Pathology (1254)
  • Pharmacology and Toxicology (2195)
  • Physiology (3260)
  • Plant Biology (7027)
  • Scientific Communication and Education (1294)
  • Synthetic Biology (1948)
  • Systems Biology (5420)
  • Zoology (1113)