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The effect of NMDA-R antagonist, MK-801, on Neuronal Mismatch along the Auditory Thalamocortical System

View ORCID ProfileGloria G Parras, View ORCID ProfileCatalina Valdés-Baizabal, View ORCID ProfileLauren Harms, View ORCID ProfilePatricia Michie, View ORCID ProfileManuel S Malmierca
doi: https://doi.org/10.1101/636068
Gloria G Parras
Cognitive and Auditory Neuroscience Laboratory, Institute of Neuroscience of Castilla y León (INCYL), Salamanca, SpainThe Salamanca Institute for Biomedical Research (IBSAL), Salamanca, Spain
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  • ORCID record for Gloria G Parras
Catalina Valdés-Baizabal
Cognitive and Auditory Neuroscience Laboratory, Institute of Neuroscience of Castilla y León (INCYL), Salamanca, SpainThe Salamanca Institute for Biomedical Research (IBSAL), Salamanca, Spain
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Lauren Harms
School of Psychology, University of Newcastle, Callaghan, NSW, Australia; Priority Centre for Brain and Mental Health Research, Callaghan, NSW, Australia; Hunter Medical Research Institute, Newcastle, NSW, Australia
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Patricia Michie
School of Psychology, University of Newcastle, Callaghan, NSW, Australia; Priority Centre for Brain and Mental Health Research, Callaghan, NSW, Australia; Hunter Medical Research Institute, Newcastle, NSW, Australia
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Manuel S Malmierca
Cognitive and Auditory Neuroscience Laboratory, Institute of Neuroscience of Castilla y León (INCYL), Salamanca, SpainThe Salamanca Institute for Biomedical Research (IBSAL), Salamanca, SpainDepartment of Cell Biology and Pathology, Faculty of Medicine, University of Salamanca, Salamanca, Spain
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  • For correspondence: msm@usal.es
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ABSTRACT

The predictive coding framework has emerged as an appealing model of mismatch negativity (MMN). It has been repeatedly observed that MMN is reduced in schizophrenia. It is believed that the molecular correlate of this reduction is a NMDA-R hypofunction, a major model of the pathophysiology of schizophrenia. We have previously demonstrated that the neuronal index of mismatch is composed of repetition suppression (RS) and prediction error (PE). Therefore, the main goal of this study was to test how the NMDA-R antagonist, MK-801, affects RS and PE in single units along the rat auditory thalamocortical pathway. Results demonstrate enhanced RS at thalamus and PE at cortex. Moreover, results demonstrate that MK-801 alters the dynamics of adaptation along the thalamocortical axis. These single unit data correlate with the recordings of large-scale responses. This study opens new avenue for future research in the development of safe compounds that target similar binding locations to MK-801.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted May 12, 2019.
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The effect of NMDA-R antagonist, MK-801, on Neuronal Mismatch along the Auditory Thalamocortical System
Gloria G Parras, Catalina Valdés-Baizabal, Lauren Harms, Patricia Michie, Manuel S Malmierca
bioRxiv 636068; doi: https://doi.org/10.1101/636068
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The effect of NMDA-R antagonist, MK-801, on Neuronal Mismatch along the Auditory Thalamocortical System
Gloria G Parras, Catalina Valdés-Baizabal, Lauren Harms, Patricia Michie, Manuel S Malmierca
bioRxiv 636068; doi: https://doi.org/10.1101/636068

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