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Specialized medial prefrontal-amygdala coordination in other-regarding decision preference

View ORCID ProfileOlga Dal Monte, Cheng-Chi J. Chu, Nicholas A. Fagan, View ORCID ProfileSteve W. C. Chang
doi: https://doi.org/10.1101/640292
Olga Dal Monte
1Department of Psychology, Yale University, New Haven, CT 06520
2Department of Psychology, University of Turin, Torino, Italy
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Cheng-Chi J. Chu
1Department of Psychology, Yale University, New Haven, CT 06520
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Nicholas A. Fagan
1Department of Psychology, Yale University, New Haven, CT 06520
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Steve W. C. Chang
1Department of Psychology, Yale University, New Haven, CT 06520
3Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06510
4Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510
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  • For correspondence: steve.chang@yale.edu
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Abstract

Social behaviors recruit multiple cognitive processes requiring coordinated interactions among brain regions. Oscillatory coupling provides one mechanism for cortical and subcortical neurons to synchronize their activity. However, it remains unknown how neurons from different nodes in the social brain network interact when making social decisions. We investigated neuronal coupling between the rostral anterior cingulate gyrus of the medial prefrontal cortex and the basolateral amygdala while monkeys expressed context-dependent positive other-regarding preference (ORP) or negative ORP impacting the reward of another monkey. We found an enhanced synchronization between the two nodes for positive ORP, but a suppressed synchronization for negative ORP. These interactions occurred in dedicated frequency channels depending on the area contributing spikes, exhibited a specific directionality of information flow associated with expressing positive ORP, and could be used to decode social decisions. These findings support that specialized coordination in the medial prefrontal-amygdala network underlies social decision preference.

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  • This is a revised manuscript.

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Posted August 31, 2019.
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Specialized medial prefrontal-amygdala coordination in other-regarding decision preference
Olga Dal Monte, Cheng-Chi J. Chu, Nicholas A. Fagan, Steve W. C. Chang
bioRxiv 640292; doi: https://doi.org/10.1101/640292
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Specialized medial prefrontal-amygdala coordination in other-regarding decision preference
Olga Dal Monte, Cheng-Chi J. Chu, Nicholas A. Fagan, Steve W. C. Chang
bioRxiv 640292; doi: https://doi.org/10.1101/640292

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