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Single-cell transcriptome analysis revealed a role of the transcription factor TOX in promoting CD8+ T-cell exhaustion in cancer

Kyungsoo Kim, Seyeon Park, Ga Min Kim, Su Myeong Park, Seong Yong Park, Da Hee Kim, Young Min Park, Yoon Woo Koh, Hye Ryun Kim, Sang-Jun Ha, Insuk Lee
doi: https://doi.org/10.1101/641316
Kyungsoo Kim
1Department of Biotechnology, College of Life Science & Biotechnology, Yonsei University, Seoul 03722, Korea
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Seyeon Park
2Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University, Seoul 03722, Korea
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Ga Min Kim
3Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03722, Korea
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Su Myeong Park
3Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03722, Korea
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Seong Yong Park
4Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Seoul 03722, Korea
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Da Hee Kim
5Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul 03722, Korea
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Young Min Park
5Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul 03722, Korea
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Yoon Woo Koh
5Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul 03722, Korea
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Hye Ryun Kim
3Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03722, Korea
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Sang-Jun Ha
2Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University, Seoul 03722, Korea
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  • For correspondence: insuklee@yonsei.ac.kr sjha@yonsei.ac.kr
Insuk Lee
1Department of Biotechnology, College of Life Science & Biotechnology, Yonsei University, Seoul 03722, Korea
6Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul 03722, Korea
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  • For correspondence: insuklee@yonsei.ac.kr sjha@yonsei.ac.kr
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Article Information

doi 
https://doi.org/10.1101/641316
History 
  • May 17, 2019.

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Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.

Author Information

  1. Kyungsoo Kim1,#,
  2. Seyeon Park2,#,
  3. Ga Min Kim3,
  4. Su Myeong Park3,
  5. Seong Yong Park4,
  6. Da Hee Kim5,
  7. Young Min Park5,
  8. Yoon Woo Koh5,
  9. Hye Ryun Kim3,
  10. Sang-Jun Ha2,* and
  11. Insuk Lee1,6,*
  1. 1Department of Biotechnology, College of Life Science & Biotechnology, Yonsei University, Seoul 03722, Korea
  2. 2Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University, Seoul 03722, Korea
  3. 3Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03722, Korea
  4. 4Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Seoul 03722, Korea
  5. 5Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul 03722, Korea
  6. 6Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul 03722, Korea
  1. ↵*Correspondence to: Insuk Lee, Department of Biotechnology, College of Life Science & Biotechnology, Yonsei University, Seoul 03722, Korea. Tel: +82-2-2123-5559 insuklee{at}yonsei.ac.kr, Sang-Jun Ha, Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University, Seoul 03722, Korea. Tel: +82-2-2123-2696 sjha{at}yonsei.ac.kr
  1. ↵# These authors contributed equally.

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Single-cell transcriptome analysis revealed a role of the transcription factor TOX in promoting CD8+ T-cell exhaustion in cancer
Kyungsoo Kim, Seyeon Park, Ga Min Kim, Su Myeong Park, Seong Yong Park, Da Hee Kim, Young Min Park, Yoon Woo Koh, Hye Ryun Kim, Sang-Jun Ha, Insuk Lee
bioRxiv 641316; doi: https://doi.org/10.1101/641316
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Single-cell transcriptome analysis revealed a role of the transcription factor TOX in promoting CD8+ T-cell exhaustion in cancer
Kyungsoo Kim, Seyeon Park, Ga Min Kim, Su Myeong Park, Seong Yong Park, Da Hee Kim, Young Min Park, Yoon Woo Koh, Hye Ryun Kim, Sang-Jun Ha, Insuk Lee
bioRxiv 641316; doi: https://doi.org/10.1101/641316

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