Single-cell transcriptome analysis revealed a role of the transcription factor TOX in promoting CD8+ T-cell exhaustion in cancer

Kyungsoo Kim; Seyeon Park; Ga Min Kim; Su Myeong Park; Seong Yong Park; Da Hee Kim; Young Min Park; Yoon Woo Koh; Hye Ryun Kim; Sang-Jun Ha; Insuk Lee

doi:10.1101/641316

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Single-cell transcriptome analysis revealed a role of the transcription factor TOX in promoting CD8⁺ T-cell exhaustion in cancer

Kyungsoo Kim, Seyeon Park, Ga Min Kim, Su Myeong Park, Seong Yong Park, Da Hee Kim, Young Min Park, Yoon Woo Koh, Hye Ryun Kim, Sang-Jun Ha, Insuk Lee

doi: https://doi.org/10.1101/641316

Kyungsoo Kim

1Department of Biotechnology, College of Life Science & Biotechnology, Yonsei University, Seoul 03722, Korea

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Seyeon Park

2Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University, Seoul 03722, Korea

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Ga Min Kim

3Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03722, Korea

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Su Myeong Park

3Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03722, Korea

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Seong Yong Park

4Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Seoul 03722, Korea

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Da Hee Kim

5Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul 03722, Korea

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Young Min Park

5Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul 03722, Korea

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Yoon Woo Koh

5Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul 03722, Korea

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Hye Ryun Kim

3Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03722, Korea

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Sang-Jun Ha

2Department of Biochemistry, College of Life Science & Biotechnology, Yonsei University, Seoul 03722, Korea

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For correspondence: insuklee@yonsei.ac.kr sjha@yonsei.ac.kr

Insuk Lee

1Department of Biotechnology, College of Life Science & Biotechnology, Yonsei University, Seoul 03722, Korea

6Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul 03722, Korea

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For correspondence: insuklee@yonsei.ac.kr sjha@yonsei.ac.kr

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Single-cell transcriptome analysis revealed a role of the transcription factor TOX in promoting CD8⁺ T-cell exhaustion in cancer

Kyungsoo Kim, Seyeon Park, Ga Min Kim, Su Myeong Park, Seong Yong Park, Da Hee Kim, Young Min Park, Yoon Woo Koh, Hye Ryun Kim, Sang-Jun Ha, Insuk Lee

bioRxiv 641316; doi: https://doi.org/10.1101/641316

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Single-cell transcriptome analysis revealed a role of the transcription factor TOX in promoting CD8⁺ T-cell exhaustion in cancer

Kyungsoo Kim, Seyeon Park, Ga Min Kim, Su Myeong Park, Seong Yong Park, Da Hee Kim, Young Min Park, Yoon Woo Koh, Hye Ryun Kim, Sang-Jun Ha, Insuk Lee

bioRxiv 641316; doi: https://doi.org/10.1101/641316

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