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Area 2 of primary somatosensory cortex encodes kinematics of the whole arm

View ORCID ProfileRaeed H Chowdhury, View ORCID ProfileJoshua I Glaser, View ORCID ProfileLee E Miller
doi: https://doi.org/10.1101/643205
Raeed H Chowdhury
Department of Biomedical Engineering, Northwestern University, Evanston, IL
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Joshua I Glaser
Interdepartmental Neuroscience Program, Northwestern University, Chicago, ILDepartment of Statistics, Columbia University, New York City, NYZuckerman Mind Brain Behavior Institute, Columbia University, New York City, NY
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Lee E Miller
Department of Biomedical Engineering, Northwestern University, Evanston, ILDepartment of Physiology, Northwestern University, Chicago, ILDepartment of Physical Medicine and Rehabilitation, Northwestern University, Chicago, ILShirley Ryan AbilityLab, Chicago, IL
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  • For correspondence: lm@northwestern.edu
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Abstract

Proprioception, or the sense of body position, movement, and associated forces, remains poorly understood, despite its clear importance to making coordinated movements. In the classic model of neurons in area 2, a proprioceptive area of primary somatosensory cortex, neural activity is related simply to the movement of the hand and interaction forces it encounters during movement, similar to our conscious experience of proprioception. However, in two separate experiments, examining 1) active and passive movements and 2) reaches to targets in two different workspaces, we found that a model of area 2 activity built on kinematics of the whole arm successfully predicted how features of neural activity changed across movement conditions, while the classic hand-based model was unable to. This suggests that, unlike our conscious experience and the classic model of proprioception in cortex, neural activity in area 2 represents movement of the whole arm.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted May 20, 2019.
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Area 2 of primary somatosensory cortex encodes kinematics of the whole arm
Raeed H Chowdhury, Joshua I Glaser, Lee E Miller
bioRxiv 643205; doi: https://doi.org/10.1101/643205
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Area 2 of primary somatosensory cortex encodes kinematics of the whole arm
Raeed H Chowdhury, Joshua I Glaser, Lee E Miller
bioRxiv 643205; doi: https://doi.org/10.1101/643205

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