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Is adaptation limited by mutation? A timescale-dependent effect of genetic diversity on the adaptive substitution rate in animals

View ORCID ProfileM Rousselle, P Simion, MK Tilak, E Figuet, B Nabholz, N Galtier
doi: https://doi.org/10.1101/643619
M Rousselle
1ISEM, Univ. Montpellier, CNRS, EPHE, IRD, Montpellier, France
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  • ORCID record for M Rousselle
  • For correspondence: marjolaine.rousselle@umontpellier.fr
P Simion
1ISEM, Univ. Montpellier, CNRS, EPHE, IRD, Montpellier, France
2LEGE, Department of Biology, University of Namur, 5000 Namur, Belgium
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MK Tilak
1ISEM, Univ. Montpellier, CNRS, EPHE, IRD, Montpellier, France
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E Figuet
1ISEM, Univ. Montpellier, CNRS, EPHE, IRD, Montpellier, France
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B Nabholz
1ISEM, Univ. Montpellier, CNRS, EPHE, IRD, Montpellier, France
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N Galtier
1ISEM, Univ. Montpellier, CNRS, EPHE, IRD, Montpellier, France
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ABSTRACT

Whether adaptation is limited by the beneficial mutation supply is a long-standing question of evolutionary genetics, which is more generally related to the determination of the adaptive substitution rate and its relationship with the effective population size Ne. Empirical evidence reported so far is equivocal, with some but not all studies supporting a higher adaptive substitution rate in large-Ne than in small-Ne species.

We gathered coding sequence polymorphism data and estimated the adaptive amino-acid substitution rate ωa, in 50 species from ten distant groups of animals with markedly different population mutation rate θ. We reveal the existence of a complex, timescale dependent relationship between species adaptive substitution rate and genetic diversity. We find a positive relationship between ωa and θ among closely related species, indicating that adaptation is indeed limited by the mutation supply, but this was only true in relatively low-θ taxa. In contrast, we uncover a weak negative correlation between ωa and θ at a larger taxonomic scale. This result is consistent with Fisher’s geometrical model predictions and suggests that the proportion of beneficial mutations scales negatively with species’ long-term Ne.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted August 12, 2019.
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Is adaptation limited by mutation? A timescale-dependent effect of genetic diversity on the adaptive substitution rate in animals
M Rousselle, P Simion, MK Tilak, E Figuet, B Nabholz, N Galtier
bioRxiv 643619; doi: https://doi.org/10.1101/643619
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Is adaptation limited by mutation? A timescale-dependent effect of genetic diversity on the adaptive substitution rate in animals
M Rousselle, P Simion, MK Tilak, E Figuet, B Nabholz, N Galtier
bioRxiv 643619; doi: https://doi.org/10.1101/643619

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