Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Action representation in the mouse parieto-frontal network

View ORCID ProfileTuce Tombaz, Benjamin A. Dunn, Karoline Hovde, Ryan J. Cubero, View ORCID ProfileBartul Mimica, Pranav Mamidanna, Yasser Roudi, Jonathan R. Whitlock
doi: https://doi.org/10.1101/646414
Tuce Tombaz
1Kavli Institute for Systems Neuroscience & Centre for Neural Circuits, Norwegian University of Science and Technology, Olav Kyrres Gate 9, 7489 Trondheim, Norway
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Tuce Tombaz
  • For correspondence: tuce.tombaz@ntnu.no jonathan.whitlock@ntnu.no
Benjamin A. Dunn
1Kavli Institute for Systems Neuroscience & Centre for Neural Circuits, Norwegian University of Science and Technology, Olav Kyrres Gate 9, 7489 Trondheim, Norway
2Department of Mathematical Sciences, Norwegian University of Science and Technology, Alfred Getz’ Vei 1, 7034 Trondheim, Norway
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Karoline Hovde
1Kavli Institute for Systems Neuroscience & Centre for Neural Circuits, Norwegian University of Science and Technology, Olav Kyrres Gate 9, 7489 Trondheim, Norway
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ryan J. Cubero
1Kavli Institute for Systems Neuroscience & Centre for Neural Circuits, Norwegian University of Science and Technology, Olav Kyrres Gate 9, 7489 Trondheim, Norway
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bartul Mimica
1Kavli Institute for Systems Neuroscience & Centre for Neural Circuits, Norwegian University of Science and Technology, Olav Kyrres Gate 9, 7489 Trondheim, Norway
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Bartul Mimica
Pranav Mamidanna
3Department of Health Science and Technology, Center for Sensory-Motor Interaction, Aalborg University, D3, Fedrik Bajers Vej 7, 9920 Aalborg, Denmark
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yasser Roudi
1Kavli Institute for Systems Neuroscience & Centre for Neural Circuits, Norwegian University of Science and Technology, Olav Kyrres Gate 9, 7489 Trondheim, Norway
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jonathan R. Whitlock
1Kavli Institute for Systems Neuroscience & Centre for Neural Circuits, Norwegian University of Science and Technology, Olav Kyrres Gate 9, 7489 Trondheim, Norway
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: tuce.tombaz@ntnu.no jonathan.whitlock@ntnu.no
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

The posterior parietal cortex (PPC), along with anatomically linked frontal areas, form a cortical network which mediates several functions that support goal-directed behavior, including sensorimotor transformations and decision making. In primates, this network also links performed and observed actions via mirror neurons, which fire both when an individual performs an action and when they observe the same action performed by a conspecific. Mirror neurons are thought to be important for social learning and imitation, but it is not known whether mirror-like neurons occur in similar networks in other species that can learn socially, such as rodents. We therefore imaged Ca2+ responses in large neural ensembles in PPC and secondary motor cortex (M2) while mice performed and observed several actions in pellet reaching and wheel running tasks. In all animals, we found spatially overlapping neural ensembles in PPC and M2 that robustly encoded a variety of naturalistic behaviors, and that subsets of cells could stably encode multiple actions. However, neural responses to the same set of observed actions were absent in both brain areas, and across animals. Statistical modeling analyses also showed that performed actions, especially those that were task-specific, outperformed observed actions in predicting neural responses. Overall, these findings show that performed and observed actions do not drive the same cells in the parieto-frontal network in mice, and suggest that sensorimotor mirroring in the mammalian cortex may have evolved more recently, and only in certain species.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted May 24, 2019.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Action representation in the mouse parieto-frontal network
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Action representation in the mouse parieto-frontal network
Tuce Tombaz, Benjamin A. Dunn, Karoline Hovde, Ryan J. Cubero, Bartul Mimica, Pranav Mamidanna, Yasser Roudi, Jonathan R. Whitlock
bioRxiv 646414; doi: https://doi.org/10.1101/646414
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Action representation in the mouse parieto-frontal network
Tuce Tombaz, Benjamin A. Dunn, Karoline Hovde, Ryan J. Cubero, Bartul Mimica, Pranav Mamidanna, Yasser Roudi, Jonathan R. Whitlock
bioRxiv 646414; doi: https://doi.org/10.1101/646414

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (4113)
  • Biochemistry (8815)
  • Bioengineering (6519)
  • Bioinformatics (23462)
  • Biophysics (11789)
  • Cancer Biology (9209)
  • Cell Biology (13322)
  • Clinical Trials (138)
  • Developmental Biology (7436)
  • Ecology (11409)
  • Epidemiology (2066)
  • Evolutionary Biology (15150)
  • Genetics (10436)
  • Genomics (14043)
  • Immunology (9171)
  • Microbiology (22154)
  • Molecular Biology (8812)
  • Neuroscience (47569)
  • Paleontology (350)
  • Pathology (1428)
  • Pharmacology and Toxicology (2491)
  • Physiology (3730)
  • Plant Biology (8080)
  • Scientific Communication and Education (1437)
  • Synthetic Biology (2221)
  • Systems Biology (6037)
  • Zoology (1253)