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Cancer/Testis Antigens Differentially Expressed in Prostate Cancer: Potential New Biomarkers and Targets for Immunotherapies

Luciane T. Kagohara, Neil M. Carleton, Sayuri Takahashi, Takumi Shiraishi, Steven M. Mooney, Robert L. Vessella, Robert H. Getzenberg, Prakash Kulkarni, Robert W. Veltri
doi: https://doi.org/10.1101/646869
Luciane T. Kagohara
1Brady Urological Institute, Department of Urology, Johns Hopkins University; Baltimore, MD; (L.T.K.); (N.M.C.); (S.T.); (T.S.); (S.M.M.); (R.G.); (P.K.); (R.W.V.)
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  • For correspondence: ltsukam1@jhmi.edu ltsukam1@jhmi.edu nmc-42@pitt.edu t-sayuri@athena.ocn.ne.jp takumi14@koto.kpu-m.ac.jp s2mooney@uwaterloo.ca rgetzenb@nova.edu pkulkarni@coh.org rveltri11@gmail.com
Neil M. Carleton
1Brady Urological Institute, Department of Urology, Johns Hopkins University; Baltimore, MD; (L.T.K.); (N.M.C.); (S.T.); (T.S.); (S.M.M.); (R.G.); (P.K.); (R.W.V.)
2Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA; (N.M.C.)
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Sayuri Takahashi
1Brady Urological Institute, Department of Urology, Johns Hopkins University; Baltimore, MD; (L.T.K.); (N.M.C.); (S.T.); (T.S.); (S.M.M.); (R.G.); (P.K.); (R.W.V.)
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Takumi Shiraishi
1Brady Urological Institute, Department of Urology, Johns Hopkins University; Baltimore, MD; (L.T.K.); (N.M.C.); (S.T.); (T.S.); (S.M.M.); (R.G.); (P.K.); (R.W.V.)
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Steven M. Mooney
1Brady Urological Institute, Department of Urology, Johns Hopkins University; Baltimore, MD; (L.T.K.); (N.M.C.); (S.T.); (T.S.); (S.M.M.); (R.G.); (P.K.); (R.W.V.)
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Robert L. Vessella
3Department of Urology, University of Washington, Seattle, WA; (R.L.V.)
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  • For correspondence: vessella@uw.edu
Robert H. Getzenberg
1Brady Urological Institute, Department of Urology, Johns Hopkins University; Baltimore, MD; (L.T.K.); (N.M.C.); (S.T.); (T.S.); (S.M.M.); (R.G.); (P.K.); (R.W.V.)
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Prakash Kulkarni
1Brady Urological Institute, Department of Urology, Johns Hopkins University; Baltimore, MD; (L.T.K.); (N.M.C.); (S.T.); (T.S.); (S.M.M.); (R.G.); (P.K.); (R.W.V.)
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Robert W. Veltri
1Brady Urological Institute, Department of Urology, Johns Hopkins University; Baltimore, MD; (L.T.K.); (N.M.C.); (S.T.); (T.S.); (S.M.M.); (R.G.); (P.K.); (R.W.V.)
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Abstract

Current clinical tests for prostate cancer (PCa), such as the PSA test, are not fully capable of discerning patients that are highly likely to develop metastatic prostate cancer (MPCa). Hence, more accurate prediction tools are needed to provide treatment strategies that are focused on the different risk groups. Cancer/testis antigens (CTAs) are expressed during embryonic development and present aberrant expression in cancer making them ideal tumor specific biomarkers. Here, the potential use of a panel of CTAs as a biomarker for PCa detection as well as metastasis prediction is explored. We initially identified eight CTAs (CEP55, NUF2, PAGE4, PBK, RQCD1, SPAG4, SSX2 and TTK) that are differentially expressed in MPCa when compared to local disease and used this panel to compare the gene and protein expression profiles in paired PCa and normal adjacent prostate tissue. We identified differential expression of all eight CTAs at the protein level when comparing 80 paired samples of PCa and the adjacent non-cancer tissue. Using multiple logistic regression we also show that a panel of these CTAs present high accuracy to discriminate normal from tumor samples. In summary, this study provides evidence that a panel of CTAs, differentially expressed in aggressive PCa, is a potential biomarker for diagnosis and prognosis to be used in combination with the current clinically available tools and is also a potential target for immunotherapy development.

Footnotes

  • Update to the Results by adding a new section "CTA expression and association with Gleason score" and a new figure (Figure 5).

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Cancer/Testis Antigens Differentially Expressed in Prostate Cancer: Potential New Biomarkers and Targets for Immunotherapies
Luciane T. Kagohara, Neil M. Carleton, Sayuri Takahashi, Takumi Shiraishi, Steven M. Mooney, Robert L. Vessella, Robert H. Getzenberg, Prakash Kulkarni, Robert W. Veltri
bioRxiv 646869; doi: https://doi.org/10.1101/646869
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Cancer/Testis Antigens Differentially Expressed in Prostate Cancer: Potential New Biomarkers and Targets for Immunotherapies
Luciane T. Kagohara, Neil M. Carleton, Sayuri Takahashi, Takumi Shiraishi, Steven M. Mooney, Robert L. Vessella, Robert H. Getzenberg, Prakash Kulkarni, Robert W. Veltri
bioRxiv 646869; doi: https://doi.org/10.1101/646869

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