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Neural trajectories in the supplementary motor area and primary motor cortex exhibit distinct geometries, compatible with different classes of computation

Abigail A. Russo, Ramin Khajeh, Sean R. Bittner, Sean M. Perkins, John P. Cunningham, Laurence F. Abbott, Mark M. Churchland
doi: https://doi.org/10.1101/650002
Abigail A. Russo
1Department of Neuroscience, Columbia University Medical Center, New York, New York 10032, USA
2Zuckerman Mind Brain Behavior Institute, Columbia University, New York, New York 10027, USA
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Ramin Khajeh
1Department of Neuroscience, Columbia University Medical Center, New York, New York 10032, USA
2Zuckerman Mind Brain Behavior Institute, Columbia University, New York, New York 10027, USA
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Sean R. Bittner
1Department of Neuroscience, Columbia University Medical Center, New York, New York 10032, USA
2Zuckerman Mind Brain Behavior Institute, Columbia University, New York, New York 10027, USA
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Sean M. Perkins
2Zuckerman Mind Brain Behavior Institute, Columbia University, New York, New York 10027, USA
3Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
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John P. Cunningham
2Zuckerman Mind Brain Behavior Institute, Columbia University, New York, New York 10027, USA
4Grossman Center for the Statistics of Mind, Columbia University, New York, New York 10027, USA
5Center for Theoretical Neuroscience, Columbia University Medical Center, New York, New York 10032, USA
6Department of Statistics, Columbia University, New York, New York 10027, USA
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Laurence F. Abbott
1Department of Neuroscience, Columbia University Medical Center, New York, New York 10032, USA
2Zuckerman Mind Brain Behavior Institute, Columbia University, New York, New York 10027, USA
5Center for Theoretical Neuroscience, Columbia University Medical Center, New York, New York 10032, USA
7Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
8Kavli Institute for Brain Science, Columbia University Medical Center, New York, New York 10032, USA
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Mark M. Churchland
1Department of Neuroscience, Columbia University Medical Center, New York, New York 10032, USA
2Zuckerman Mind Brain Behavior Institute, Columbia University, New York, New York 10027, USA
4Grossman Center for the Statistics of Mind, Columbia University, New York, New York 10027, USA
8Kavli Institute for Brain Science, Columbia University Medical Center, New York, New York 10032, USA
9David Mahoney Center for Brain and Behavior Research, Columbia University Medical Center, New York, New York 10032, USA
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  • For correspondence: mc3502@columbia.edu
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Article Information

doi 
https://doi.org/10.1101/650002
History 
  • May 24, 2019.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Abigail A. Russo1,2,
  2. Ramin Khajeh1,2,
  3. Sean R. Bittner1,2,
  4. Sean M. Perkins2,3,
  5. John P. Cunningham2,4,5,6,
  6. Laurence F. Abbott1,2,5,7,8 and
  7. Mark M. Churchland1,2,4,8,9,*
  1. 1Department of Neuroscience, Columbia University Medical Center, New York, New York 10032, USA
  2. 2Zuckerman Mind Brain Behavior Institute, Columbia University, New York, New York 10027, USA
  3. 3Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
  4. 4Grossman Center for the Statistics of Mind, Columbia University, New York, New York 10027, USA
  5. 5Center for Theoretical Neuroscience, Columbia University Medical Center, New York, New York 10032, USA
  6. 6Department of Statistics, Columbia University, New York, New York 10027, USA
  7. 7Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, New York 10032, USA
  8. 8Kavli Institute for Brain Science, Columbia University Medical Center, New York, New York 10032, USA
  9. 9David Mahoney Center for Brain and Behavior Research, Columbia University Medical Center, New York, New York 10032, USA
  1. ↵*Correspondence: mc3502{at}columbia.edu
  1. Author contributions: M.M.C. conceived the experiments; A.A.R. collected data with assistance by S.M.P.; A.A.R. and M.M.C. designed data analyses, with assistance from J.P.C. and L.F.A.; A.A.R. performed analyses of empirical data. K.R. and S.R.B. trained network models, supervised by L.F.A. and J.P.C.; A.A.R. and M.M.C. wrote the paper. All authors contributed to editing of the manuscript.

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Posted May 24, 2019.
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Neural trajectories in the supplementary motor area and primary motor cortex exhibit distinct geometries, compatible with different classes of computation
Abigail A. Russo, Ramin Khajeh, Sean R. Bittner, Sean M. Perkins, John P. Cunningham, Laurence F. Abbott, Mark M. Churchland
bioRxiv 650002; doi: https://doi.org/10.1101/650002
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Neural trajectories in the supplementary motor area and primary motor cortex exhibit distinct geometries, compatible with different classes of computation
Abigail A. Russo, Ramin Khajeh, Sean R. Bittner, Sean M. Perkins, John P. Cunningham, Laurence F. Abbott, Mark M. Churchland
bioRxiv 650002; doi: https://doi.org/10.1101/650002

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