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The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens

View ORCID ProfileNaihui Zhou, Yuxiang Jiang, Timothy R Bergquist, Alexandra J Lee, View ORCID ProfileBalint Z Kacsoh, Alex W Crocker, View ORCID ProfileKimberley A Lewis, View ORCID ProfileGeorge Georghiou, Huy N Nguyen, View ORCID ProfileMd Nafiz Hamid, Larry Davis, Tunca Dogan, Volkan Atalay, Ahmet S Rifaioglu, Alperen Dalkiran, Rengul Cetin-Atalay, Chengxin Zhang, Rebecca L Hurto, Peter L Freddolino, Yang Zhang, Prajwal Bhat, Fran Supek, José M Fernández, Branislava Gemovic, Vladimir R Perovic, Radoslav S Davidović, Neven Sumonja, Nevena Veljkovic, Ehsaneddin Asgari, Mohammad RK Mofrad, Giuseppe Profiti, Castrense Savojardo, Pier Luigi Martelli, Rita Casadio, Florian Boecker, Indika Kahanda, Natalie Thurlby, Alice C McHardy, Alexandre Renaux, Rabie Saidi, Julian Gough, Alex A Freitas, Magdalena Antczak, Fabio Fabris, Mark N Wass, Jie Hou, Jianlin Cheng, Jie Hou, Zheng Wang, Alfonso E Romero, Alberto Paccanaro, Haixuan Yang, Tatyana Goldberg, Chenguang Zhao, Liisa Holm, Petri Törönen, Alan J Medlar, Elaine Zosa, Itamar Borukhov, Ilya Novikov, Angela Wilkins, Olivier Lichtarge, Po-Han Chi, Wei-Cheng Tseng, Michal Linial, Peter W Rose, Christophe Dessimoz, Vedrana Vidulin, Saso Dzeroski, Ian Sillitoe, Sayoni Das, Jonathan Gill Lees, David T Jones, Cen Wan, Domenico Cozzetto, Rui Fa, Mateo Torres, Alex Wiarwick Vesztrocy, Jose Manuel Rodriguez, Michael L Tress, Marco Frasca, Marco Notaro, Giuliano Grossi, Alessandro Petrini, Matteo Re, Giorgio Valentini, Marco Mesiti, Daniel B Roche, Jonas Reeb, David W Ritchie, Sabeur Aridhi, Seyed Ziaeddin Alborzi, Marie-Dominique Devignes, Da Chen Emily Koo, Richard Bonneau, Vladimir Gligorijević, Meet Barot, Hai Fang, Stefano Toppo, Enrico Lavezzo, Marco Falda, Michele Berselli, Silvio CE Tosatto, Marco Carraro, Damiano Piovesan, Hafeez Ur Rehman, Qizhong Mao, Shanshan Zhang, Slobodan Vucetic, Gage S Black, Dane Jo, Dallas J Larsen, Ashton R Omdahl, Luke W Sagers, Erica Suh, Jonathan B Dayton, Liam J McGuffin, Danielle A Brackenridge, Patricia C Babbitt, Jeffrey M Yunes, Paolo Fontana, Feng Zhang, Shanfeng Zhu, Ronghui You, Zihan Zhang, Suyang Dai, Shuwei Yao, Weidong Tian, Renzhi Cao, Caleb Chandler, Miguel Amezola, Devon Johnson, Jia-Ming Chang, Wen-Hung Liao, Yi-Wei Liu, Stefano Pascarelli, Yotam Frank, Robert Hoehndorf, Maxat Kulmanov, Imane Boudellioua, Gianfranco Politano, Stefano Di Carlo, Alfredo Benso, Kai Hakala, Filip Ginter, Farrokh Mehryary, Suwisa Kaewphan, Jari Björne, Hans Moen, Martti E E Tolvanen, Tapio Salakoski, Daisuke Kihara, Aashish Jain, Tomislav Šmuc, Adrian Altenhoff, Asa Ben-Hur, View ORCID ProfileBurkhard Rost, View ORCID ProfileSteven E Brenner, View ORCID ProfileChristine A Orengo, Constance J Jeffery, View ORCID ProfileGiovanni Bosco, View ORCID ProfileDeborah A Hogan, View ORCID ProfileMaria J Martin, Claire O’Donovan, View ORCID ProfileSean D Mooney, View ORCID ProfileCasey S Greene, View ORCID ProfilePredrag Radivojac, View ORCID ProfileIddo Friedberg
doi: https://doi.org/10.1101/653105
Naihui Zhou
1Veterinary Microbiology and Preventive Medicine, Iowa State University
2Program in Bioinformatics and Computational Biology, Iowa State University, Ames, IA, USA
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  • ORCID record for Naihui Zhou
Yuxiang Jiang
3Indiana University Bloomington, Bloomington, Indiana, USA
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Timothy R Bergquist
4Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, USA
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Alexandra J Lee
5Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA
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Balint Z Kacsoh
6Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth
7Department of Molecular and Systems Biology, Hanover, NH, USA
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  • ORCID record for Balint Z Kacsoh
Alex W Crocker
8Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA
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Kimberley A Lewis
8Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA
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  • ORCID record for Kimberley A Lewis
George Georghiou
9European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, United Kingdom
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  • ORCID record for George Georghiou
Huy N Nguyen
1Veterinary Microbiology and Preventive Medicine, Iowa State University
10Program in Computer Science, Iowa State University, Ames, IA, USA
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Md Nafiz Hamid
1Veterinary Microbiology and Preventive Medicine, Iowa State University
2Program in Bioinformatics and Computational Biology, Iowa State University, Ames, IA, USA
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Larry Davis
2Program in Bioinformatics and Computational Biology, Iowa State University, Ames, IA, USA
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Tunca Dogan
12Graduate School of Informatics, Middle East Technical University (METU)
13European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI)
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Volkan Atalay
14Department of Computer Engineering, Middle East Technical University (METU)
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Ahmet S Rifaioglu
14Department of Computer Engineering, Middle East Technical University (METU)
16Department of Computer Engineering, Iskenderun Technical University, Hatay, Turkey, Ankara, Turkey
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Alperen Dalkiran
17Department of Computer Engineering, Middle East Technical University (METU), Ankara, Turkey
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Rengul Cetin-Atalay
18CanSyL, Graduate School of Informatics, Middle East Technical University (METU), Ankara, Select a State or Province, Turkey
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Chengxin Zhang
19Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA
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Rebecca L Hurto
20Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA
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Peter L Freddolino
21Department of Biological Chemistry, University of Michigan
22Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA
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Yang Zhang
23Department of Computational Medicine and Bioinformatics, University of Michigan
24Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA
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Prajwal Bhat
25Achira Labs, Bangalore, India
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Fran Supek
26Institute for Research in Biomedicine (IRB Barcelona)
27Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
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José M Fernández
28INB Coordination Unit, Life Sciences Department, Barcelona Supercomputing Center
29(former) INB GN2, Structural and Computational Biology Programme, Spanish National Cancer Research Centre, Barcelona, Catalonia, Spain
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Branislava Gemovic
30Laboratory for Bioinformatics and Computational Chemistry, Institute of Nuclear Sciences VINCA, University of Belgrade, Belgrade, Serbia
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Vladimir R Perovic
31Laboratory for Bionformatics and Computational Chemistry, Institute of Nuclear Sciences VINCA, University of Belgrade, Belgrade, Serbia
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Radoslav S Davidović
30Laboratory for Bioinformatics and Computational Chemistry, Institute of Nuclear Sciences VINCA, University of Belgrade, Belgrade, Serbia
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Neven Sumonja
30Laboratory for Bioinformatics and Computational Chemistry, Institute of Nuclear Sciences VINCA, University of Belgrade, Belgrade, Serbia
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Nevena Veljkovic
30Laboratory for Bioinformatics and Computational Chemistry, Institute of Nuclear Sciences VINCA, University of Belgrade, Belgrade, Serbia
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Ehsaneddin Asgari
32Molecular Cell Biomechanics Laboratory, Departments of Bioengineering, University of California Berkeley
33Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Berkeley, CA, USA
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Mohammad RK Mofrad
34Departments of Bioengineering and Mechanical Engineering, Berkeley, CA, USA
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Giuseppe Profiti
35Bologna Biocomputing Group, Department of Pharmacy and Biotechnology, University of Bologna, Italy
36National Research Council, IBIOM, Bologna, Italy
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Castrense Savojardo
37Bologna Biocomputing Group, Department of Pharmacy and Biotechnology, University of Bologna, Italy, Bologna, Italy
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Pier Luigi Martelli
37Bologna Biocomputing Group, Department of Pharmacy and Biotechnology, University of Bologna, Italy, Bologna, Italy
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Rita Casadio
37Bologna Biocomputing Group, Department of Pharmacy and Biotechnology, University of Bologna, Italy, Bologna, Italy
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Florian Boecker
38University of Bonn: INRES Crop Bioinformatics, Bonn, North Rhine-Westphalia, Germany
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Indika Kahanda
39Gianforte School of Computing, Montana State University, Bozeman, Montana, USA
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Natalie Thurlby
40University of Bristol, Computer Science, Bristol, Bristol, United Kingdom
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Alice C McHardy
41Computational Biology of Infection Research, Helmholtz Centre for Infection Research
42RESIST, DFG Cluster of Excellence 2155, Brunswick, Germany
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Alexandre Renaux
43Interuniversity Institute of Bioinformatics in Brussels, Universite libre de Bruxelles - Vrije Universiteit Brussel
44Machine Learning Group, Artificial Intelligence lab, Vrije Universiteit Brussel, Brussels, Belgium
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Rabie Saidi
45European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK
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Julian Gough
46MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
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Alex A Freitas
47University of Kent, School of Computing, Canterbury, United Kingdom
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Magdalena Antczak
48School of Biosciences, University of Kent, Canterbury, United Kingdom
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Fabio Fabris
47University of Kent, School of Computing, Canterbury, United Kingdom
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Mark N Wass
49School of Biosciences, University of Kent, Canterbury, Kent, United Kingdom
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Jie Hou
50University of Missouri, Computer Science, Columbia, Missouri, USA
51Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, Missouri, USA
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Jianlin Cheng
51Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, Missouri, USA
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Jie Hou
50University of Missouri, Computer Science, Columbia, Missouri, USA
51Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, Missouri, USA
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Zheng Wang
52University of Miami, Coral Gables, Florida, USA
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Alfonso E Romero
53Centre for Systems and Synthetic Biology, Department of Computer Science, Royal Holloway, University of London, Egham, Surrey, United Kingdom
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Alberto Paccanaro
54Centre for Systems and Synthetic Biology, Department of Computer Science, Royal Holloway, University of London, Egham, United Kingdom
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Haixuan Yang
55School of Mathematics, Statistics and Applied Mathematics. National University of Ireland, Galway, Galway, Ireland
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Tatyana Goldberg
56Department of Informatics, Bioinformatics & Computational Biology, Technical University of Munich, Germany, Munich, Germany
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Chenguang Zhao
57School of Computing Sciences and Computer Engineering, University of Southern Mississippi, Hattiesburg, Mississippi, USA
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Liisa Holm
58Institute of Biotechnology, University of Helsinki, Helsinki, Finland
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Petri Törönen
58Institute of Biotechnology, University of Helsinki, Helsinki, Finland
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Alan J Medlar
58Institute of Biotechnology, University of Helsinki, Helsinki, Finland
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Elaine Zosa
58Institute of Biotechnology, University of Helsinki, Helsinki, Finland
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Itamar Borukhov
59Compugen Ltd., Holon, Israel
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Ilya Novikov
60Baylor College of Medicine, Department of Biochemistry and Molecular Biology, Houston, TX, USA
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Angela Wilkins
61Baylor College of Medicine, Department of Molecular and Human Genetics, Houston, TX, USA
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Olivier Lichtarge
61Baylor College of Medicine, Department of Molecular and Human Genetics, Houston, TX, USA
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Po-Han Chi
62National TsingHua University, Hsinchu, Taiwan
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Wei-Cheng Tseng
63Department of Electrical Engineering in National Tsing Hua University, Hsinchu City, Taiwan
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Michal Linial
64The Hebrew University of Jerusalem, Jerusalem, Israel
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Peter W Rose
65University of California San Diego, San Diego Supercomputer Center, La Jolla, California, USA
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Christophe Dessimoz
66Department of Computational Biology and Center for Integrative Genomics, University of Lausanne, Switzerland
67Department of Genetics, Evolution & Environment, and Department of Computer Science, University College London, UK, Lausanne, Switzerland
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Vedrana Vidulin
68Department of Knowledge Technologies, Jozef Stefan Institute, Ljubljana, Slovenia
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Saso Dzeroski
69Jozef Stefan Institute
70Jozef Stefan International Postgraduate School, Ljubljana, Slovenia
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Ian Sillitoe
71Research Dept.of Structural and Molecular Biology, University College London, London, England
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Sayoni Das
72Research Dept.of Structural and Molecular Biology, University College London, London, United Kingdom
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Jonathan Gill Lees
73Research Dept.of Structural and Molecular Biology, University College London
74Oxford Brookes University, Department of Health and Life Sciences, Oxford, UK
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David T Jones
75University College London, Department of Computer Science
76The Francis Crick Institute, Biomedical Data Science Laboratory, London, United Kingdom
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Cen Wan
75University College London, Department of Computer Science
76The Francis Crick Institute, Biomedical Data Science Laboratory, London, United Kingdom
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Domenico Cozzetto
75University College London, Department of Computer Science
76The Francis Crick Institute, Biomedical Data Science Laboratory, London, United Kingdom
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Rui Fa
75University College London, Department of Computer Science
76The Francis Crick Institute, Biomedical Data Science Laboratory, London, United Kingdom
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Mateo Torres
53Centre for Systems and Synthetic Biology, Department of Computer Science, Royal Holloway, University of London, Egham, Surrey, United Kingdom
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Alex Wiarwick Vesztrocy
77Department of Genetics, Evolution and Environment, University College London, Gower Street, London, WC1E 6BT, United Kingdom
78SIB Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland, London, United Kingdom
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Jose Manuel Rodriguez
79Cardiovascular Proteomics Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain
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Michael L Tress
80Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
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Marco Frasca
81Università degli Studi di Milano - Computer Science Dept. - AnacletoLab, Milan, Milan, Italy
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Marco Notaro
81Università degli Studi di Milano - Computer Science Dept. - AnacletoLab, Milan, Milan, Italy
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Giuliano Grossi
81Università degli Studi di Milano - Computer Science Dept. - AnacletoLab, Milan, Milan, Italy
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Alessandro Petrini
81Università degli Studi di Milano - Computer Science Dept. - AnacletoLab, Milan, Milan, Italy
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Matteo Re
81Università degli Studi di Milano - Computer Science Dept. - AnacletoLab, Milan, Milan, Italy
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Giorgio Valentini
81Università degli Studi di Milano - Computer Science Dept. - AnacletoLab, Milan, Milan, Italy
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Marco Mesiti
81Università degli Studi di Milano - Computer Science Dept. - AnacletoLab, Milan, Milan, Italy
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Daniel B Roche
82Institut de Biologie Computationnelle, LIRMM, CNRS-UMR 5506, Université de Montpellier, Montpellier, France
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Jonas Reeb
83Department of Informatics, Chair of Bioinformatics and Computational Biology, Technical University of Munich, Germany, Munich, Germany
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David W Ritchie
84University of Lorraine, CNRS, Inria, LORIA, 54000 Nancy, France, Nancy, France
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Sabeur Aridhi
84University of Lorraine, CNRS, Inria, LORIA, 54000 Nancy, France, Nancy, France
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Seyed Ziaeddin Alborzi
85University of Lorraine, CNRS, Inria, LORIA, 54000 Nancy, France
86University of Lorraine, Nancy, Lorraine, France
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Marie-Dominique Devignes
85University of Lorraine, CNRS, Inria, LORIA, 54000 Nancy, France
87Inria, Nancy, France
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Da Chen Emily Koo
88Department of Biology, New York University, New York, NY, USA
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Richard Bonneau
89NYU Center for Data Science, New York NY 10010
90Flatiron Institute, CCB, NY NY 10010, New York, NY, USA
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Vladimir Gligorijević
91Center for Computational Biology (CCB), Flatiron Institute, Simons Foundation, New York, NY, USA
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Meet Barot
92Center for Data Science, New York University, New York, NY 10011, USA, New York, NY, USA
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Hai Fang
93Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK
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Stefano Toppo
94University of Padova, Department of Molecular Medicine, Padova, Italy
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Enrico Lavezzo
94University of Padova, Department of Molecular Medicine, Padova, Italy
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Marco Falda
95Dept. of Biology - University of Padova, Padova, Italy
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Michele Berselli
94University of Padova, Department of Molecular Medicine, Padova, Italy
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Silvio CE Tosatto
96Department of Biomedical Sciences, University of Padua
97CNR Institute of Neuroscience, Padova, Italy
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Marco Carraro
98Department of Biomedical Sciences, University of Padua, Padova, Padova, Italy
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Damiano Piovesan
99Department of Biomedical Sciences, University of Padua, Padua, Italy
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Hafeez Ur Rehman
100Department of Computer Science, National University of Computer and Emerging Sciences, Peshawar, Pakistan., Peshawar, Khyber Pakhtoonkhwa, Pakistan
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Qizhong Mao
101Temple University
102University of California, Riverside, Philadelphia, PA, USA
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Shanshan Zhang
103Temple University, Philadelphia, PA, USA
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Slobodan Vucetic
104Temple University, Department of Computer and Information Sciences, Philadelphia, PA, USA
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Gage S Black
105Department of Biology, Brigham Young University
106Bioinformatics Research Group, Provo, UT, USA
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Dane Jo
105Department of Biology, Brigham Young University
106Bioinformatics Research Group, Provo, UT, USA
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105Department of Biology, Brigham Young University
106Bioinformatics Research Group, Provo, UT, USA
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105Department of Biology, Brigham Young University
106Bioinformatics Research Group, Provo, UT, USA
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105Department of Biology, Brigham Young University
106Bioinformatics Research Group, Provo, UT, USA
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105Department of Biology, Brigham Young University
106Bioinformatics Research Group, Provo, UT, USA
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105Department of Biology, Brigham Young University
106Bioinformatics Research Group, Provo, UT, USA
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107School of Biological Sciences, University of Reading, Reading, England, United Kingdom
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107School of Biological Sciences, University of Reading, Reading, England, United Kingdom
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108Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco
109Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA
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Jeffrey M Yunes
110UC Berkeley - UCSF Graduate Program in Bioengineering, University of California, San Francisco, CA 94158, USA
111Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA, San Francisco, California, USA
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Paolo Fontana
112Research and Innovation Center, Edmund Mach Foundation, 38010S. Michele all’Adige, Italy, San Michele all’Adige, Italy
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Feng Zhang
113State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University
114Department of Pediatrics, Brain Tumor Center, Division of Experimental Hematology and Cancer Biology, Shanghai, Shanghai, China
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115School of Computer Science and Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, China
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115School of Computer Science and Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, China
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115School of Computer Science and Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, China
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116School of Computer Science and Shanghai Key Lab of Intelligent Information Processing, Fudan University, ShangHai, China
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117School of Computer Science and Shanghai Key Lab of Intelligent Information Processing, Fudan University, Shanghai, Shanghai, China
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Weidong Tian
113State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University
114Department of Pediatrics, Brain Tumor Center, Division of Experimental Hematology and Cancer Biology, Shanghai, Shanghai, China
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Renzhi Cao
118Pacific Lutheran University, Department of Computer Science, Tacoma, WA, USA
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118Pacific Lutheran University, Department of Computer Science, Tacoma, WA, USA
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118Pacific Lutheran University, Department of Computer Science, Tacoma, WA, USA
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118Pacific Lutheran University, Department of Computer Science, Tacoma, WA, USA
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119Department of Computer Science, National Chengchi University, Taipei, Taiwan
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119Department of Computer Science, National Chengchi University, Taipei, Taiwan
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119Department of Computer Science, National Chengchi University, Taipei, Taiwan
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120Okinawa Institute of Science and Technology, Tancha, Okinawa, Japan
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121Tel Aviv University, Tel Aviv, Israel
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122Computer, Electrical and Mathematical Sciences & Engineering Division, Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia
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Maxat Kulmanov
123King Abdullah University of Science and Technology, Computational Bioscience Research Center, Thuwal, Jeddah, Saudi Arabia
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Imane Boudellioua
124Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology, Thuwal, Saudi Arabia
125Computer, Electrical and Mathematical Sciences Engineering Division (CEMSE), King Abdullah University of Science and Technology, Thuwal, Saudi Arabia, Thuwal, Saudi Arabia
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126Politecnico di Torino, Control and Computer Engineering Department, Torino, TO, Italy
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126Politecnico di Torino, Control and Computer Engineering Department, Torino, TO, Italy
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126Politecnico di Torino, Control and Computer Engineering Department, Torino, TO, Italy
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127University of Turku, Department of Future Technologies, Turku NLP Group
128University of Turku Graduate School (UTUGS), Turku, Finland
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127University of Turku, Department of Future Technologies, Turku NLP Group
129University of Turku, Turku, Finland
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127University of Turku, Department of Future Technologies, Turku NLP Group
128University of Turku Graduate School (UTUGS), Turku, Finland
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130Turku Centre for Computer Science (TUCS)
131University of Turku, Department of Future Technologies, Turku, Finland
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Jari Björne
132Department of Future Technologies, Faculty of Science and Engineering, University of Turku, FI-20014, Turku, Finland
133Turku Centre for Computer Science (TUCS), Agora, Vesilinnantie 3, FI-20500 TURKU, Turku, Finland
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134University of Turku, Faculty of Science and Engineering, Department of Future Technologies, Turku, Finland
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135University of Turku, Department of Future Technologies, Turku, Finland
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Tapio Salakoski
132Department of Future Technologies, Faculty of Science and Engineering, University of Turku, FI-20014, Turku, Finland
133Turku Centre for Computer Science (TUCS), Agora, Vesilinnantie 3, FI-20500 TURKU, Turku, Finland
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Daisuke Kihara
136Department of Biological Sciences, Department of Computer Science, Purdue University, West Lafayette, IN, 47907, USA
137Department of Pediatrics, University of Cincinnati, Cincinnati, OH, 45229, USA, West Lafayette, IN, USA
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138Department of Computer Science, Purdue University, West Lafayette, IN, USA
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139Division of Electronics, Rudjer Boskovic Institute, Zagreb, Croatia
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140Department of Computer Science, ETH Zurich
141SIB Swiss Institute of Bioinformatics, Zurich, Switzerland
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142Department of Computer Science, Colorado State University, Fort Collins, CO, USA
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143Department of Informatics, Technical University of Munich, Germany
144Institute for Food and Plant Sciences WZW, Technical University of Munich, Weihenstephan, Germany, Munich, Germany
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145University of California, Berkeley, Berkeley, CA, USA
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Christine A Orengo
72Research Dept.of Structural and Molecular Biology, University College London, London, United Kingdom
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Constance J Jeffery
146Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA
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147Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, US
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Deborah A Hogan
8Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA
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Maria J Martin
9European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, United Kingdom
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Claire O’Donovan
9European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, United Kingdom
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Sean D Mooney
4Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, USA
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Casey S Greene
148Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania
149Childhood Cancer Data Lab, Alex’s Lemonade Stand Foundation, Philadelphia, Pennsylvania, USA
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Predrag Radivojac
150Khoury College of Computer Sciences, Northeastern University, Boston, MA, USA
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Iddo Friedberg
1Veterinary Microbiology and Preventive Medicine, Iowa State University
2Program in Bioinformatics and Computational Biology, Iowa State University, Ames, IA, USA
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  • For correspondence: idoerg@iastate.edu
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The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens
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The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens
Naihui Zhou, Yuxiang Jiang, Timothy R Bergquist, Alexandra J Lee, Balint Z Kacsoh, Alex W Crocker, Kimberley A Lewis, George Georghiou, Huy N Nguyen, Md Nafiz Hamid, Larry Davis, Tunca Dogan, Volkan Atalay, Ahmet S Rifaioglu, Alperen Dalkiran, Rengul Cetin-Atalay, Chengxin Zhang, Rebecca L Hurto, Peter L Freddolino, Yang Zhang, Prajwal Bhat, Fran Supek, José M Fernández, Branislava Gemovic, Vladimir R Perovic, Radoslav S Davidović, Neven Sumonja, Nevena Veljkovic, Ehsaneddin Asgari, Mohammad RK Mofrad, Giuseppe Profiti, Castrense Savojardo, Pier Luigi Martelli, Rita Casadio, Florian Boecker, Indika Kahanda, Natalie Thurlby, Alice C McHardy, Alexandre Renaux, Rabie Saidi, Julian Gough, Alex A Freitas, Magdalena Antczak, Fabio Fabris, Mark N Wass, Jie Hou, Jianlin Cheng, Jie Hou, Zheng Wang, Alfonso E Romero, Alberto Paccanaro, Haixuan Yang, Tatyana Goldberg, Chenguang Zhao, Liisa Holm, Petri Törönen, Alan J Medlar, Elaine Zosa, Itamar Borukhov, Ilya Novikov, Angela Wilkins, Olivier Lichtarge, Po-Han Chi, Wei-Cheng Tseng, Michal Linial, Peter W Rose, Christophe Dessimoz, Vedrana Vidulin, Saso Dzeroski, Ian Sillitoe, Sayoni Das, Jonathan Gill Lees, David T Jones, Cen Wan, Domenico Cozzetto, Rui Fa, Mateo Torres, Alex Wiarwick Vesztrocy, Jose Manuel Rodriguez, Michael L Tress, Marco Frasca, Marco Notaro, Giuliano Grossi, Alessandro Petrini, Matteo Re, Giorgio Valentini, Marco Mesiti, Daniel B Roche, Jonas Reeb, David W Ritchie, Sabeur Aridhi, Seyed Ziaeddin Alborzi, Marie-Dominique Devignes, Da Chen Emily Koo, Richard Bonneau, Vladimir Gligorijević, Meet Barot, Hai Fang, Stefano Toppo, Enrico Lavezzo, Marco Falda, Michele Berselli, Silvio CE Tosatto, Marco Carraro, Damiano Piovesan, Hafeez Ur Rehman, Qizhong Mao, Shanshan Zhang, Slobodan Vucetic, Gage S Black, Dane Jo, Dallas J Larsen, Ashton R Omdahl, Luke W Sagers, Erica Suh, Jonathan B Dayton, Liam J McGuffin, Danielle A Brackenridge, Patricia C Babbitt, Jeffrey M Yunes, Paolo Fontana, Feng Zhang, Shanfeng Zhu, Ronghui You, Zihan Zhang, Suyang Dai, Shuwei Yao, Weidong Tian, Renzhi Cao, Caleb Chandler, Miguel Amezola, Devon Johnson, Jia-Ming Chang, Wen-Hung Liao, Yi-Wei Liu, Stefano Pascarelli, Yotam Frank, Robert Hoehndorf, Maxat Kulmanov, Imane Boudellioua, Gianfranco Politano, Stefano Di Carlo, Alfredo Benso, Kai Hakala, Filip Ginter, Farrokh Mehryary, Suwisa Kaewphan, Jari Björne, Hans Moen, Martti E E Tolvanen, Tapio Salakoski, Daisuke Kihara, Aashish Jain, Tomislav Šmuc, Adrian Altenhoff, Asa Ben-Hur, Burkhard Rost, Steven E Brenner, Christine A Orengo, Constance J Jeffery, Giovanni Bosco, Deborah A Hogan, Maria J Martin, Claire O’Donovan, Sean D Mooney, Casey S Greene, Predrag Radivojac, Iddo Friedberg
bioRxiv 653105; doi: https://doi.org/10.1101/653105
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The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens
Naihui Zhou, Yuxiang Jiang, Timothy R Bergquist, Alexandra J Lee, Balint Z Kacsoh, Alex W Crocker, Kimberley A Lewis, George Georghiou, Huy N Nguyen, Md Nafiz Hamid, Larry Davis, Tunca Dogan, Volkan Atalay, Ahmet S Rifaioglu, Alperen Dalkiran, Rengul Cetin-Atalay, Chengxin Zhang, Rebecca L Hurto, Peter L Freddolino, Yang Zhang, Prajwal Bhat, Fran Supek, José M Fernández, Branislava Gemovic, Vladimir R Perovic, Radoslav S Davidović, Neven Sumonja, Nevena Veljkovic, Ehsaneddin Asgari, Mohammad RK Mofrad, Giuseppe Profiti, Castrense Savojardo, Pier Luigi Martelli, Rita Casadio, Florian Boecker, Indika Kahanda, Natalie Thurlby, Alice C McHardy, Alexandre Renaux, Rabie Saidi, Julian Gough, Alex A Freitas, Magdalena Antczak, Fabio Fabris, Mark N Wass, Jie Hou, Jianlin Cheng, Jie Hou, Zheng Wang, Alfonso E Romero, Alberto Paccanaro, Haixuan Yang, Tatyana Goldberg, Chenguang Zhao, Liisa Holm, Petri Törönen, Alan J Medlar, Elaine Zosa, Itamar Borukhov, Ilya Novikov, Angela Wilkins, Olivier Lichtarge, Po-Han Chi, Wei-Cheng Tseng, Michal Linial, Peter W Rose, Christophe Dessimoz, Vedrana Vidulin, Saso Dzeroski, Ian Sillitoe, Sayoni Das, Jonathan Gill Lees, David T Jones, Cen Wan, Domenico Cozzetto, Rui Fa, Mateo Torres, Alex Wiarwick Vesztrocy, Jose Manuel Rodriguez, Michael L Tress, Marco Frasca, Marco Notaro, Giuliano Grossi, Alessandro Petrini, Matteo Re, Giorgio Valentini, Marco Mesiti, Daniel B Roche, Jonas Reeb, David W Ritchie, Sabeur Aridhi, Seyed Ziaeddin Alborzi, Marie-Dominique Devignes, Da Chen Emily Koo, Richard Bonneau, Vladimir Gligorijević, Meet Barot, Hai Fang, Stefano Toppo, Enrico Lavezzo, Marco Falda, Michele Berselli, Silvio CE Tosatto, Marco Carraro, Damiano Piovesan, Hafeez Ur Rehman, Qizhong Mao, Shanshan Zhang, Slobodan Vucetic, Gage S Black, Dane Jo, Dallas J Larsen, Ashton R Omdahl, Luke W Sagers, Erica Suh, Jonathan B Dayton, Liam J McGuffin, Danielle A Brackenridge, Patricia C Babbitt, Jeffrey M Yunes, Paolo Fontana, Feng Zhang, Shanfeng Zhu, Ronghui You, Zihan Zhang, Suyang Dai, Shuwei Yao, Weidong Tian, Renzhi Cao, Caleb Chandler, Miguel Amezola, Devon Johnson, Jia-Ming Chang, Wen-Hung Liao, Yi-Wei Liu, Stefano Pascarelli, Yotam Frank, Robert Hoehndorf, Maxat Kulmanov, Imane Boudellioua, Gianfranco Politano, Stefano Di Carlo, Alfredo Benso, Kai Hakala, Filip Ginter, Farrokh Mehryary, Suwisa Kaewphan, Jari Björne, Hans Moen, Martti E E Tolvanen, Tapio Salakoski, Daisuke Kihara, Aashish Jain, Tomislav Šmuc, Adrian Altenhoff, Asa Ben-Hur, Burkhard Rost, Steven E Brenner, Christine A Orengo, Constance J Jeffery, Giovanni Bosco, Deborah A Hogan, Maria J Martin, Claire O’Donovan, Sean D Mooney, Casey S Greene, Predrag Radivojac, Iddo Friedberg
bioRxiv 653105; doi: https://doi.org/10.1101/653105

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