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Computational Saturation Mutagenesis to predict structural consequences of systematic mutations on protein stability and rifampin interactions in the β subunit of RNA polymerase in Mycobacterium leprae
View ORCID ProfileSundeep Chaitanya Vedithi, Carlos H. M. Rodrigues, Stephanie Portelli, Marcin J. Skwark, Madhusmita Das, View ORCID ProfileDavid B. Ascher, Tom L Blundell, Sony Malhotra
doi: https://doi.org/10.1101/654095
Sundeep Chaitanya Vedithi
1Department of Biochemistry, University of Cambridge, Tennis Court Rd., CB2 IGA, UK
Carlos H. M. Rodrigues
2Department of Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, Parkville, VIC 3052, Australia
3Structural Biology and Bioinformatics, Baker Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia
Stephanie Portelli
2Department of Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, Parkville, VIC 3052, Australia
3Structural Biology and Bioinformatics, Baker Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia
Marcin J. Skwark
1Department of Biochemistry, University of Cambridge, Tennis Court Rd., CB2 IGA, UK
Madhusmita Das
4Molecular Biology Laboratory, Schieffelin Institute of Heath-Research and Leprosy Center, Karigiri, Vellore, Tamil Nadu, India 632106
David B. Ascher
1Department of Biochemistry, University of Cambridge, Tennis Court Rd., CB2 IGA, UK
2Department of Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, Parkville, VIC 3052, Australia
3Structural Biology and Bioinformatics, Baker Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia
Tom L Blundell
1Department of Biochemistry, University of Cambridge, Tennis Court Rd., CB2 IGA, UK
Sony Malhotra
1Department of Biochemistry, University of Cambridge, Tennis Court Rd., CB2 IGA, UK
5Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, University of London, London UK, WC1E 7HX
Article usage
Posted June 11, 2019.
Computational Saturation Mutagenesis to predict structural consequences of systematic mutations on protein stability and rifampin interactions in the β subunit of RNA polymerase in Mycobacterium leprae
Sundeep Chaitanya Vedithi, Carlos H. M. Rodrigues, Stephanie Portelli, Marcin J. Skwark, Madhusmita Das, David B. Ascher, Tom L Blundell, Sony Malhotra
bioRxiv 654095; doi: https://doi.org/10.1101/654095
Computational Saturation Mutagenesis to predict structural consequences of systematic mutations on protein stability and rifampin interactions in the β subunit of RNA polymerase in Mycobacterium leprae
Sundeep Chaitanya Vedithi, Carlos H. M. Rodrigues, Stephanie Portelli, Marcin J. Skwark, Madhusmita Das, David B. Ascher, Tom L Blundell, Sony Malhotra
bioRxiv 654095; doi: https://doi.org/10.1101/654095
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