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Dynamical Patterning Modules and Network Motifs as joint determinants of development: lessons from an aggregative bacterium

Alejandra Guzmán-Herrera, Juan A. Arias Del Angel, Natsuko Rivera-Yoshida, Mariana Benítez, Alessio Franci
doi: https://doi.org/10.1101/655381
Alejandra Guzmán-Herrera
1Departamento de Matemáticas, Facultad de Ciencias, Universidad Nacional Autónoma de México
5MRC Laboratory for Molecular Cell Biology, University College London, London, UK
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Juan A. Arias Del Angel
2Laboratorio Nacional de Ciencias de la Sostenibilidad, Instituto de Ecología, Universidad Nacional Autónoma de México
3Centro de Ciencias de la Complejidad, Universidad Nacional Autónoma de México
4Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México
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Natsuko Rivera-Yoshida
1Departamento de Matemáticas, Facultad de Ciencias, Universidad Nacional Autónoma de México
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Mariana Benítez
2Laboratorio Nacional de Ciencias de la Sostenibilidad, Instituto de Ecología, Universidad Nacional Autónoma de México
3Centro de Ciencias de la Complejidad, Universidad Nacional Autónoma de México
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Alessio Franci
1Departamento de Matemáticas, Facultad de Ciencias, Universidad Nacional Autónoma de México
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  • For correspondence: afranci@ciencias.unam.mx
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Abstract

Development and evolution are dynamical processes under the continuous control of organismic and environmental factors. Generic physical processes, associated with biological materials and certain genes or molecules, provide a morphological template for the evolution and development of organism forms. Generic dynamical behaviors, associated with recurring network motifs, provide a temporal template for the regulation and coordination of biological processes. The role of generic physical processes and their associated molecules in development is the topic of the Dynamical Patterning Module (DPM) framework. The role of generic dynamical behaviors in biological regulation is studied via the identification of the associated Network Motifs (NM). We propose a joint DPM-NM perspective on the emergence and regulation of multicellularity focusing on a multicellular aggregative bacterium, Myxococcus xanthus. Understanding M. xanthus development as a dynamical process embedded in a physical substrate provides novel insights into the interaction between developmental regulatory networks and generic physical processes in the evolutionary transition to multicellularity.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted May 05, 2020.
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Dynamical Patterning Modules and Network Motifs as joint determinants of development: lessons from an aggregative bacterium
Alejandra Guzmán-Herrera, Juan A. Arias Del Angel, Natsuko Rivera-Yoshida, Mariana Benítez, Alessio Franci
bioRxiv 655381; doi: https://doi.org/10.1101/655381
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Dynamical Patterning Modules and Network Motifs as joint determinants of development: lessons from an aggregative bacterium
Alejandra Guzmán-Herrera, Juan A. Arias Del Angel, Natsuko Rivera-Yoshida, Mariana Benítez, Alessio Franci
bioRxiv 655381; doi: https://doi.org/10.1101/655381

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