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Influence of genetic variants on gene expression in human pancreatic islets – implications for type 2 diabetes
View ORCID ProfileAna Viñuela, View ORCID ProfileArushi Varshney, View ORCID ProfileMartijn van de Bunt, View ORCID ProfileRashmi B. Prasad, Olof Asplund, Amanda Bennett, View ORCID ProfileMichael Boehnke, View ORCID ProfileAndrew Brown, View ORCID ProfileMichael R. Erdos, João Fadista, View ORCID ProfileOla Hansson, Gad Hatem, Cédric Howald, Apoorva K. Iyengar, Paul Johnson, Ulrika Krus, View ORCID ProfilePatrick E. MacDonald, View ORCID ProfileAnubha Mahajan, Jocelyn E. Manning Fox, View ORCID ProfileNarisu Narisu, View ORCID ProfileVibe Nylander, View ORCID ProfilePeter Orchard, Nikolay Oskolkov, View ORCID ProfileNikolaos I. Panousis, Anthony Payne, View ORCID ProfileMichael L. Stitzel, Swarooparani Vadlamudi, View ORCID ProfileRyan Welch, View ORCID ProfileFrancis S. Collins, View ORCID ProfileKaren L. Mohlke, View ORCID ProfileAnna L. Gloyn, View ORCID ProfileLaura J. Scott, View ORCID ProfileEmmanouil T. Dermitzakis, Leif Groop, View ORCID ProfileStephen C.J. Parker, View ORCID ProfileMark I. McCarthy
doi: https://doi.org/10.1101/655670
Ana Viñuela
1Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland
2Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, 1211 Geneva, Switzerland
3Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland
Arushi Varshney
4Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109
Martijn van de Bunt
5Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK
6Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 7LE, UK
7Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, OX3 7LE, UK
Rashmi B. Prasad
8Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden
Olof Asplund
8Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden
Amanda Bennett
5Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK
Michael Boehnke
9Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109
Andrew Brown
1Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland
2Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, 1211 Geneva, Switzerland
3Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland
Michael R. Erdos
10Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA
João Fadista
8Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden
12Department of Genetics, University of North Carolina, Chapel Hill, NC 27599
Ola Hansson
8Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden
Gad Hatem
8Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden
Cédric Howald
1Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland
2Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, 1211 Geneva, Switzerland
3Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland
Apoorva K. Iyengar
12Department of Genetics, University of North Carolina, Chapel Hill, NC 27599
Paul Johnson
5Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK
Ulrika Krus
8Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden
Patrick E. MacDonald
13Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada
Anubha Mahajan
5Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK
Jocelyn E. Manning Fox
13Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada
Narisu Narisu
10Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA
Vibe Nylander
6Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 7LE, UK
Peter Orchard
14Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI 48109
Nikolay Oskolkov
8Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden
Nikolaos I. Panousis
1Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland
2Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, 1211 Geneva, Switzerland
3Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland
Anthony Payne
5Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK
Michael L. Stitzel
15The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032
16Department of Genetics and Genome Sciences, Institute for Systems Genomics, University of Connecticut, Farmington, CT 06032
Swarooparani Vadlamudi
12Department of Genetics, University of North Carolina, Chapel Hill, NC 27599
Ryan Welch
9Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109
Francis S. Collins
10Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA
Karen L. Mohlke
12Department of Genetics, University of North Carolina, Chapel Hill, NC 27599
Anna L. Gloyn
5Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK
6Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 7LE, UK
7Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, OX3 7LE, UK
Laura J. Scott
9Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109
Emmanouil T. Dermitzakis
1Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland
2Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, 1211 Geneva, Switzerland
3Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland
Leif Groop
8Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden
17Finnish Institute for Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland
Stephen C.J. Parker
4Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109
14Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI 48109
Mark I. McCarthy
5Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK
6Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 7LE, UK
7Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, OX3 7LE, UK
Article usage
Posted May 31, 2019.
Influence of genetic variants on gene expression in human pancreatic islets – implications for type 2 diabetes
Ana Viñuela, Arushi Varshney, Martijn van de Bunt, Rashmi B. Prasad, Olof Asplund, Amanda Bennett, Michael Boehnke, Andrew Brown, Michael R. Erdos, João Fadista, Ola Hansson, Gad Hatem, Cédric Howald, Apoorva K. Iyengar, Paul Johnson, Ulrika Krus, Patrick E. MacDonald, Anubha Mahajan, Jocelyn E. Manning Fox, Narisu Narisu, Vibe Nylander, Peter Orchard, Nikolay Oskolkov, Nikolaos I. Panousis, Anthony Payne, Michael L. Stitzel, Swarooparani Vadlamudi, Ryan Welch, Francis S. Collins, Karen L. Mohlke, Anna L. Gloyn, Laura J. Scott, Emmanouil T. Dermitzakis, Leif Groop, Stephen C.J. Parker, Mark I. McCarthy
bioRxiv 655670; doi: https://doi.org/10.1101/655670
Influence of genetic variants on gene expression in human pancreatic islets – implications for type 2 diabetes
Ana Viñuela, Arushi Varshney, Martijn van de Bunt, Rashmi B. Prasad, Olof Asplund, Amanda Bennett, Michael Boehnke, Andrew Brown, Michael R. Erdos, João Fadista, Ola Hansson, Gad Hatem, Cédric Howald, Apoorva K. Iyengar, Paul Johnson, Ulrika Krus, Patrick E. MacDonald, Anubha Mahajan, Jocelyn E. Manning Fox, Narisu Narisu, Vibe Nylander, Peter Orchard, Nikolay Oskolkov, Nikolaos I. Panousis, Anthony Payne, Michael L. Stitzel, Swarooparani Vadlamudi, Ryan Welch, Francis S. Collins, Karen L. Mohlke, Anna L. Gloyn, Laura J. Scott, Emmanouil T. Dermitzakis, Leif Groop, Stephen C.J. Parker, Mark I. McCarthy
bioRxiv 655670; doi: https://doi.org/10.1101/655670
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