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Mitochondrial Genome Diversity in the Central Siberian Plateau with Particular Reference to Prehistory of Northernmost Eurasia

S. V. Dryomov, A. M. Nazhmidenova, E. B. Starikovskaya, S. A. Shalaurova, N. Rohland, S. Mallick, R. Bernardos, A. P. Derevianko, D. Reich, R. Sukernik
doi: https://doi.org/10.1101/656181
S. V. Dryomov
1Laboratory of Human Molecular Genetics, Institute of Molecular and Cellular Biology, SBRAS, Novosibirsk, Russian Federation
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A. M. Nazhmidenova
1Laboratory of Human Molecular Genetics, Institute of Molecular and Cellular Biology, SBRAS, Novosibirsk, Russian Federation
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E. B. Starikovskaya
1Laboratory of Human Molecular Genetics, Institute of Molecular and Cellular Biology, SBRAS, Novosibirsk, Russian Federation
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S. A. Shalaurova
1Laboratory of Human Molecular Genetics, Institute of Molecular and Cellular Biology, SBRAS, Novosibirsk, Russian Federation
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N. Rohland
2Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
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S. Mallick
2Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
3Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
4Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
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R. Bernardos
2Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
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A. P. Derevianko
5Institute of Archaeology and Ethnography, SBRAS, Novosibirsk, Russian Federation
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D. Reich
2Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
3Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
4Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
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R. Sukernik
1Laboratory of Human Molecular Genetics, Institute of Molecular and Cellular Biology, SBRAS, Novosibirsk, Russian Federation
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  • For correspondence: sukernik@mcb.nsc.ru
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Abstract

The Central Siberian Plateau was last geographic area in Eurasia to become habitable by modern humans after the Last Glacial Maximum (LGM). Through comprehensive mitochondrial DNA genomes retained in indigenous Siberian populations, the Ket, Tofalar, and Todzhi - we explored genetic links between the Yenisei-Sayan region and Northeast Eurasia over the last 10,000 years. Accordingly, we generated 218 new complete mtDNA sequences and placed them into compound phylogenies along with 7 newly obtained and 70 published ancient mt genomes. Our findings reflect the origins and expansion history of mtDNA lineages that evolved in South-Central Siberia, as well as multiple phases of connections between this region and distant parts of Eurasia. Our result illustrates the importance of jointly sampling modern and prehistoric specimens to fully measure the past genetic diversity and to reconstruct the process of peopling of the high latitudes of the Siberian subcontinent.

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Posted May 31, 2019.
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Mitochondrial Genome Diversity in the Central Siberian Plateau with Particular Reference to Prehistory of Northernmost Eurasia
S. V. Dryomov, A. M. Nazhmidenova, E. B. Starikovskaya, S. A. Shalaurova, N. Rohland, S. Mallick, R. Bernardos, A. P. Derevianko, D. Reich, R. Sukernik
bioRxiv 656181; doi: https://doi.org/10.1101/656181
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Mitochondrial Genome Diversity in the Central Siberian Plateau with Particular Reference to Prehistory of Northernmost Eurasia
S. V. Dryomov, A. M. Nazhmidenova, E. B. Starikovskaya, S. A. Shalaurova, N. Rohland, S. Mallick, R. Bernardos, A. P. Derevianko, D. Reich, R. Sukernik
bioRxiv 656181; doi: https://doi.org/10.1101/656181

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