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Placenta microbiome diversity is associated with maternal pre-pregnancy obesity and placenta biogeography

Paula A. Benny, Fadhl M. Al-Akwaa, Corbin Dirkx, Ryan J. Schlueter, Thomas K. Wolfgruber, Ingrid Y. Chern, Suzie Hoops, Dan Knights, Lana X. Garmire
doi: https://doi.org/10.1101/659797
Paula A. Benny
University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USA
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Fadhl M. Al-Akwaa
Department of Computational Medicine and Bioinformatics, North Campus Research Complex, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI 48105 USA
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Corbin Dirkx
University of Minnesota Genomics Center, University of Minnesota-Twin Cities, 312 Church St SE, Minneapolis, MN 55455
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Ryan J. Schlueter
Department of Obstetrics and Gynaecology, University of Hawaii, 1319 Punahou Street, Honolulu, HI 96826, USAAtlanta Perinatal Associates, Atlanta, GA
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Thomas K. Wolfgruber
University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USA
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Ingrid Y. Chern
Department of Computational Medicine and Bioinformatics, North Campus Research Complex, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI 48105 USA
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Suzie Hoops
BioTechnology Institute, College of Biological Sciences, University of Minnesota, Minneapolis, MN, United StatesDepartment of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, United States
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Dan Knights
BioTechnology Institute, College of Biological Sciences, University of Minnesota, Minneapolis, MN, United StatesDepartment of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, United States
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Lana X. Garmire
University of Minnesota Genomics Center, University of Minnesota-Twin Cities, 312 Church St SE, Minneapolis, MN 55455
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  • For correspondence: lgarmire@med.umich.edu
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Abstract

Recently there has been considerable debate in the scientific community regarding the placenta as the host of a unique microbiome. No studies have addressed the associations of clinical conditions such as maternal obesity, or localizations on the placental microbiome. We examined the placental microbiome in a multi-ethnic maternal pre-pregnant obesity cohort using controls for environmental contaminants and an optimized microbiome protocol to enrich low bacterial biomass samples. We confirmed that a distinct placenta microbiome does exist, as compared to the environmental background. The placenta microbiome consists predominantly of Lactobacillus, Enterococcus and Chryseobacterium. Moreover, the microbiome in the placentas of obese pre-pregnant mothers are less diverse when compared to those of mothers of normal pre-pregnancy weight. Lastly, microbiome richness also decreases from the maternal side to fetal side. In summary, our study reveals associations of placental microbiome with placenta biogeography and with maternal pre-pregnant obesity.

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Posted June 04, 2019.
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Placenta microbiome diversity is associated with maternal pre-pregnancy obesity and placenta biogeography
Paula A. Benny, Fadhl M. Al-Akwaa, Corbin Dirkx, Ryan J. Schlueter, Thomas K. Wolfgruber, Ingrid Y. Chern, Suzie Hoops, Dan Knights, Lana X. Garmire
bioRxiv 659797; doi: https://doi.org/10.1101/659797
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Placenta microbiome diversity is associated with maternal pre-pregnancy obesity and placenta biogeography
Paula A. Benny, Fadhl M. Al-Akwaa, Corbin Dirkx, Ryan J. Schlueter, Thomas K. Wolfgruber, Ingrid Y. Chern, Suzie Hoops, Dan Knights, Lana X. Garmire
bioRxiv 659797; doi: https://doi.org/10.1101/659797

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