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Non-invasive recording from the human olfactory bulb

View ORCID ProfileBehzad Iravani, View ORCID ProfileArtin Arshamian, View ORCID ProfileKathrin Ohla, View ORCID ProfileDonald A. Wilson, View ORCID ProfileJohan N. Lundström
doi: https://doi.org/10.1101/660050
Behzad Iravani
aDepartment of Clinical Neuroscience, Karolinska Institutet, 17177, Stockholm, Sweden
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  • For correspondence: Behzad.Iravani@ki.se Johan.Lundstrom@ki.se
Artin Arshamian
aDepartment of Clinical Neuroscience, Karolinska Institutet, 17177, Stockholm, Sweden
bDepartment of Psychology, Stockholm University, 10691, Stockholm, Sweden
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Kathrin Ohla
cResearch Center Jülich, Institute of Neuroscience and Medicine (INM-3), Cognitive Neuroscience, Jülich, Germany
dMonell Chemical Senses Center, Philadelphia, PA, 19104, USA
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Donald A. Wilson
eNathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
fDepartment of Child and Adolescent Psychiatry, New York University Langone Medical School, New York, NY 10016, USA
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Johan N. Lundström
aDepartment of Clinical Neuroscience, Karolinska Institutet, 17177, Stockholm, Sweden
dMonell Chemical Senses Center, Philadelphia, PA, 19104, USA
gDepartment of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA
hStockholm University Brain Imaging Centre, Stockholm University, 10691, Stockholm, Sweden
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  • ORCID record for Johan N. Lundström
  • For correspondence: Behzad.Iravani@ki.se Johan.Lundstrom@ki.se
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ABSTRACT

Current methods can, in a non-invasive manner, assess neural activity in all areas of the human brain but the olfactory bulb (OB). The OB is intimately involved in a long list of olfactory tasks, has been suggested to fulfill a role comparable to that of V1 and the thalamus in the visual system, and have been closely linked to a wide range of neuropathologies. Here we present a method for non-invasive recording of signals from the human OB with millisecond precision. We demonstrate that signals obtained via recordings from EEG electrodes at the nasal bridge represent responses from the olfactory bulb - recordings we term Electrobulbogram (EBG). The EBG is localized to the OB, is reliable, and follows response patterns demonstrated in non-human animal models. The EBG will aid future olfactory-related translational work but can also easily be implemented as an everyday clinical tool to detect pathology-related changes in human central olfactory processing in neurodegenerative diseases.

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Posted June 04, 2019.
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Non-invasive recording from the human olfactory bulb
Behzad Iravani, Artin Arshamian, Kathrin Ohla, Donald A. Wilson, Johan N. Lundström
bioRxiv 660050; doi: https://doi.org/10.1101/660050
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Non-invasive recording from the human olfactory bulb
Behzad Iravani, Artin Arshamian, Kathrin Ohla, Donald A. Wilson, Johan N. Lundström
bioRxiv 660050; doi: https://doi.org/10.1101/660050

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