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Memorability of photographs in subjective cognitive decline and mild cognitive impairment: implications for cognitive assessment

View ORCID ProfileWilma A. Bainbridge, David Berron, Hartmut Schütze, Arturo Cardenas-Blanco, Coraline Metzger, Laura Dobisch, Daniel Bittner, Wenzel Glanz, Annika Spottke, Janna Rudolph, Frederic Brosseron, Katharina Buerger, Daniel Janowitz, Klaus Fliessbach, Michael Heneka, Christoph Laske, Martina Buchmann, Oliver Peters, Dominik Diesing, Siyao Li, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Anja Schneider, Barbara Kofler, Stefan Teipel, Ingo Kilimann, Jens Wiltfang, Claudia Bartels, Steffen Wolfsgruber, Michael Wagner, Frank Jessen, Chris Baker, Emrah Düzel
doi: https://doi.org/10.1101/660365
Wilma A. Bainbridge
Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, United States
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  • ORCID record for Wilma A. Bainbridge
  • For correspondence: wilma.bainbridge@nih.gov emrah.duezel@dzne.de
David Berron
Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, GermanyGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany
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Hartmut Schütze
Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, GermanyGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany
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Arturo Cardenas-Blanco
Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, GermanyGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany
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Coraline Metzger
Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, GermanyGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg, Leipziger Str. 44, 39120 Magdeburg, GermanyDepartment of Psychiatry and Psychotherapy, University Hospital Magdeburg, Medical Faculty, Leipziger Str. 44, 39120 Magdeburg, Germany
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Laura Dobisch
German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany
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Daniel Bittner
German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Leipziger Str. 44, 39120 Magdeburg, GermanyClinic for Neurology, University Hospital Magdeburg, Medical Faculty, Leipziger Str. 44, 39120 Magdeburg, Germany
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Wenzel Glanz
German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany
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Annika Spottke
German Center for Neurodegenerative Diseases (DZNE), Bonn, Sigmund-Freud-Str. 27, 53127 Bonn, GermanyDepartment of Neurology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany
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Janna Rudolph
German Center for Neurodegenerative Diseases (DZNE), Bonn, Sigmund-Freud-Str. 27, 53127 Bonn, Germany
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Frederic Brosseron
German Center for Neurodegenerative Diseases (DZNE), Bonn, Sigmund-Freud-Str. 27, 53127 Bonn, GermanyDepartment of Neurodegeneration and Geriatric Psychiatry, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany
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Katharina Buerger
German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377 Munich, GermanyInstitute for Stroke and Dementia Research, University Hospital, LMU Munich, Feodor-Lynen-Str. 17, 81377 Munich, Germany
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Daniel Janowitz
Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Feodor-Lynen-Str. 17, 81377 Munich, Germany
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Klaus Fliessbach
Clinic for Neurology, University Hospital Magdeburg, Medical Faculty, Leipziger Str. 44, 39120 Magdeburg, Germany
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Michael Heneka
German Center for Neurodegenerative Diseases (DZNE), Bonn, Sigmund-Freud-Str. 27, 53127 Bonn, GermanyDepartment of Neurodegeneration and Geriatric Psychiatry, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany
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Christoph Laske
German Center for Neurodegenerative Diseases (DZNE), Tübingen, Otfried-Müller-Str. 23, 72076 Tübingen, GermanySection for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Calwerstr. 14, 72076 Tübingen, Germany
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Martina Buchmann
German Center for Neurodegenerative Diseases (DZNE), Tübingen, Otfried-Müller-Str. 23, 72076 Tübingen, GermanySection for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Calwerstr. 14, 72076 Tübingen, Germany
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Oliver Peters
German Center for Neurodegenerative Diseases (DZNE), Berlin, Charitéplatz 1, 10117 Berlin, GermanyCharité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Hindenburgdamm 30, 12203 Berlin, Germany
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Dominik Diesing
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Hindenburgdamm 30, 12203 Berlin, Germany
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Siyao Li
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Psychiatry and Psychotherapy, Hindenburgdamm 30, 12203 Berlin, Germany
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Josef Priller
German Center for Neurodegenerative Diseases (DZNE), Berlin, Charitéplatz 1, 10117 Berlin, GermanyDepartment of Psychiatry and Psychotherapy, Charité,, Charitéplatz 1, 10117 Berlin, Germany
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Eike Jakob Spruth
Department of Psychiatry and Psychotherapy, Charité,, Charitéplatz 1, 10117 Berlin, Germany
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Slawek Altenstein
German Center for Neurodegenerative Diseases (DZNE), Berlin, Charitéplatz 1, 10117 Berlin, Germany
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Anja Schneider
German Center for Neurodegenerative Diseases (DZNE), Bonn, Sigmund-Freud-Str. 27, 53127 Bonn, GermanyDepartment of Neurodegeneration and Geriatric Psychiatry, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany
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Barbara Kofler
Department of Neurodegeneration and Geriatric Psychiatry, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany
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Stefan Teipel
German Center for Neurodegenerative Diseases (DZNE), Rostock, Gehlsheimer Str. 20, 18147 Rostock, GermanyDepartment of Psychosomatic Medicine, Rostock University Medical Center, , Gehlsheimer Str. 20, 18147 Rostock, Germany
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Ingo Kilimann
German Center for Neurodegenerative Diseases (DZNE), Rostock, Gehlsheimer Str. 20, 18147 Rostock, GermanyDepartment of Psychosomatic Medicine, Rostock University Medical Center, , Gehlsheimer Str. 20, 18147 Rostock, Germany
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Jens Wiltfang
German Center for Neurodegenerative Diseases (DZNE), Goettingen, Von-Siebold-Str. 3a, 37075 Goettingen, GermanyDepartment of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Von-Siebold-Str. 5, 37075 Goettingen, Germany
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Claudia Bartels
German Center for Neurodegenerative Diseases (DZNE), Goettingen, Von-Siebold-Str. 3a, 37075 Goettingen, GermanyDepartment of Psychiatry and Psychotherapy, University Medical Center Goettingen, University of Goettingen, Von-Siebold-Str. 5, 37075 Goettingen, Germany
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Steffen Wolfsgruber
German Center for Neurodegenerative Diseases (DZNE), Bonn, Sigmund-Freud-Str. 27, 53127 Bonn, Germany
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Michael Wagner
German Center for Neurodegenerative Diseases (DZNE), Bonn, Sigmund-Freud-Str. 27, 53127 Bonn, GermanyDepartment of Neurodegeneration and Geriatric Psychiatry, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany
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Frank Jessen
German Center for Neurodegenerative Diseases (DZNE), Bonn, Sigmund-Freud-Str. 27, 53127 Bonn, GermanyDepartment of Psychiatry, University of Cologne, Medical Faculty, Kerpener Str. 62, 50924 Cologne, Germany
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Chris Baker
Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, United States
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Emrah Düzel
Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, GermanyGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg, Leipziger Str. 44, 39120 Magdeburg, GermanyInstitute of Cognitive Neuroscience, Univ. College London, London, UK
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  • For correspondence: wilma.bainbridge@nih.gov emrah.duezel@dzne.de
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Abstract

INTRODUCTION Impaired long-term memory is a defining feature of Mild Cognitive Impairment (MCI). We tested whether this impairment is item-specific, limited to some memoranda whereas some remain consistently memorable.

METHODS We conducted item-based analyses of long-term visual recognition memory. 394 participants (healthy controls (HC), Subjective Cognitive Decline (SCD), and MCI) in the multicentric DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) were tested with images from a pool of 835 photographs.

RESULTS We observed consistent memorability for images in HCs, SCDs, and MCI, predictable by a neural network trained on another healthy sample. Looking at memorability differences between groups, we identified images that could successfully categorize group membership with higher success and a substantial image reduction than the original image set.

DISCUSSION Individuals with SCD and MCI show consistent memorability for specific items, while other items show significant diagnosticity. Certain stimulus features could optimize diagnostic assessment, while others could support memory.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted June 05, 2019.
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Memorability of photographs in subjective cognitive decline and mild cognitive impairment: implications for cognitive assessment
Wilma A. Bainbridge, David Berron, Hartmut Schütze, Arturo Cardenas-Blanco, Coraline Metzger, Laura Dobisch, Daniel Bittner, Wenzel Glanz, Annika Spottke, Janna Rudolph, Frederic Brosseron, Katharina Buerger, Daniel Janowitz, Klaus Fliessbach, Michael Heneka, Christoph Laske, Martina Buchmann, Oliver Peters, Dominik Diesing, Siyao Li, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Anja Schneider, Barbara Kofler, Stefan Teipel, Ingo Kilimann, Jens Wiltfang, Claudia Bartels, Steffen Wolfsgruber, Michael Wagner, Frank Jessen, Chris Baker, Emrah Düzel
bioRxiv 660365; doi: https://doi.org/10.1101/660365
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Memorability of photographs in subjective cognitive decline and mild cognitive impairment: implications for cognitive assessment
Wilma A. Bainbridge, David Berron, Hartmut Schütze, Arturo Cardenas-Blanco, Coraline Metzger, Laura Dobisch, Daniel Bittner, Wenzel Glanz, Annika Spottke, Janna Rudolph, Frederic Brosseron, Katharina Buerger, Daniel Janowitz, Klaus Fliessbach, Michael Heneka, Christoph Laske, Martina Buchmann, Oliver Peters, Dominik Diesing, Siyao Li, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Anja Schneider, Barbara Kofler, Stefan Teipel, Ingo Kilimann, Jens Wiltfang, Claudia Bartels, Steffen Wolfsgruber, Michael Wagner, Frank Jessen, Chris Baker, Emrah Düzel
bioRxiv 660365; doi: https://doi.org/10.1101/660365

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