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Slow changes in seizure pathways in individual patients with focal epilepsy

Gabrielle M Schroeder, Beate Diehl, Fahmida A Chowdhury, John S Duncan, Jane de Tisi, Andrew J Trevelyan, Rob Forsyth, Andrew Jackson, Peter N Taylor, Yujiang Wang
doi: https://doi.org/10.1101/661371
Gabrielle M Schroeder
Interdisciplinary Computing and Complex BioSystems Group, School of Computing Science, Newcastle University, UK
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Beate Diehl
UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK
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Fahmida A Chowdhury
UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK
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John S Duncan
UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK
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Jane de Tisi
UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK
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Andrew J Trevelyan
Institute of Neuroscience, Faculty of Medical Science, Newcastle University, UK
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Rob Forsyth
Institute of Neuroscience, Faculty of Medical Science, Newcastle University, UK
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Andrew Jackson
Institute of Neuroscience, Faculty of Medical Science, Newcastle University, UK
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Peter N Taylor
Interdisciplinary Computing and Complex BioSystems Group, School of Computing Science, Newcastle University, UKUCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UKInstitute of Neuroscience, Faculty of Medical Science, Newcastle University, UK
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Yujiang Wang
Interdisciplinary Computing and Complex BioSystems Group, School of Computing Science, Newcastle University, UKUCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UKInstitute of Neuroscience, Faculty of Medical Science, Newcastle University, UK
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  • For correspondence: yujiang.wang@ncl.ac.uk
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Abstract

Personalised medicine requires that treatments adapt to not only the patient, but changing factors within each individual. In focal epilepsy, brain dynamics change over time and modulate pathological processes; however, surprisingly little is known about whether and how seizures vary in the same patient. We quantitatively compared within-subject seizure network dynamics using intracranial recordings of ∼700 seizures from 31 patients with focal epilepsy (mean 16.5 seizures/subject) and three canines with focal-onset seizures (mean 62.3 seizures/subject). In all subjects, we found variability in seizure paths through the space of possible network dynamics, producing either a spectrum or clusters of different dynamics. Seizures with similar pathways tended to occur closer together in time, independent of whether antiepileptic medication reduction occurred, but did not necessarily have similar durations or circadian profiles. Our results suggest that slow modulatory processes shape within-subject seizure dynamics, leading to variable seizure pathways that may require tailored treatment approaches.

Footnotes

  • http://dx.doi.org/10.5281/zenodo.3240102

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted June 06, 2019.
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Slow changes in seizure pathways in individual patients with focal epilepsy
Gabrielle M Schroeder, Beate Diehl, Fahmida A Chowdhury, John S Duncan, Jane de Tisi, Andrew J Trevelyan, Rob Forsyth, Andrew Jackson, Peter N Taylor, Yujiang Wang
bioRxiv 661371; doi: https://doi.org/10.1101/661371
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Slow changes in seizure pathways in individual patients with focal epilepsy
Gabrielle M Schroeder, Beate Diehl, Fahmida A Chowdhury, John S Duncan, Jane de Tisi, Andrew J Trevelyan, Rob Forsyth, Andrew Jackson, Peter N Taylor, Yujiang Wang
bioRxiv 661371; doi: https://doi.org/10.1101/661371

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