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A Single Cell Transcriptomic Atlas Characterizes Aging Tissues in the Mouse

The Tabula Muris consortium, Angela Oliveira Pisco, Nicholas Schaum, Aaron McGeever, Jim Karkanias, Norma F. Neff, Spyros Darmanis, Tony Wyss-Coray, Stephen R. Quake
doi: https://doi.org/10.1101/661728
1Chan Zuckerberg Biohub, San Francisco, California, USA
Angela Oliveira Pisco
1Chan Zuckerberg Biohub, San Francisco, California, USA
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Nicholas Schaum
2Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, USA
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Aaron McGeever
1Chan Zuckerberg Biohub, San Francisco, California, USA
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Jim Karkanias
1Chan Zuckerberg Biohub, San Francisco, California, USA
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Norma F. Neff
1Chan Zuckerberg Biohub, San Francisco, California, USA
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Spyros Darmanis
1Chan Zuckerberg Biohub, San Francisco, California, USA
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  • For correspondence: steve@quake-lab.org twc@stanford.edu spyros.darmanis@czbiohub.org
Tony Wyss-Coray
3Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA
4Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, California, USA
5Center for Tissue Regeneration, Repair, and Restoration, V.A. Palo Alto Healthcare System, Palo Alto, California, USA
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  • For correspondence: steve@quake-lab.org twc@stanford.edu spyros.darmanis@czbiohub.org
Stephen R. Quake
1Chan Zuckerberg Biohub, San Francisco, California, USA
6Department of Bioengineering, Stanford University, Stanford, California, USA
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  • For correspondence: steve@quake-lab.org twc@stanford.edu spyros.darmanis@czbiohub.org
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Abstract

Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death 1. Despite rapid advances over recent years 2, many of the molecular and cellular processes which underlie progressive loss of healthy physiology are poorly understood. To gain a better insight into these processes we have created a single cell transcriptomic atlas across the life span of Mus musculus which includes data from 18 tissues and organs. We discovered cell-specific changes occurring across multiple cell types and organs, as well as age related changes in the cellular composition of different organs. Using single-cell transcriptomic data we were able to assess cell type specific manifestations of different hallmarks of aging, such as senescence 3, changes in the activity of metabolic pathways 4, depletion of stem-cell populations 5, genomic instability 6 and the role of inflammation as well as other changes in the organism’s immune system2. This Tabula Muris Senis provides a wealth of new molecular information about how the most significant hallmarks of aging are reflected in a broad range of tissues and cell types.

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  • https://tabula-muris-senis.ds.czbiohub.org/

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted June 08, 2019.
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A Single Cell Transcriptomic Atlas Characterizes Aging Tissues in the Mouse
The Tabula Muris consortium, Angela Oliveira Pisco, Nicholas Schaum, Aaron McGeever, Jim Karkanias, Norma F. Neff, Spyros Darmanis, Tony Wyss-Coray, Stephen R. Quake
bioRxiv 661728; doi: https://doi.org/10.1101/661728
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A Single Cell Transcriptomic Atlas Characterizes Aging Tissues in the Mouse
The Tabula Muris consortium, Angela Oliveira Pisco, Nicholas Schaum, Aaron McGeever, Jim Karkanias, Norma F. Neff, Spyros Darmanis, Tony Wyss-Coray, Stephen R. Quake
bioRxiv 661728; doi: https://doi.org/10.1101/661728

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