Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

A Single Cell Transcriptomic Atlas Characterizes Aging Tissues in the Mouse

The Tabula Muris Consortium, Angela Oliveira Pisco, Aaron McGeever, Nicholas Schaum, Jim Karkanias, Norma F Neff, Spyros Darmanis, Tony Wyss-Coray, Stephen R Quake
doi: https://doi.org/10.1101/661728
1Chan Zuckerberg Biohub, San Francisco, California, USA
Angela Oliveira Pisco
1Chan Zuckerberg Biohub, San Francisco, California, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: angela.oliveira.pisco@gmail.com
Aaron McGeever
1Chan Zuckerberg Biohub, San Francisco, California, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nicholas Schaum
2Stanford University School of Medicine, Stanford, California, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jim Karkanias
1Chan Zuckerberg Biohub, San Francisco, California, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Norma F Neff
1Chan Zuckerberg Biohub, San Francisco, California, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Spyros Darmanis
1Chan Zuckerberg Biohub, San Francisco, California, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tony Wyss-Coray
2Stanford University School of Medicine, Stanford, California, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stephen R Quake
1Chan Zuckerberg Biohub, San Francisco, California, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Data/Code
  • Preview PDF
Loading

Abstract

Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death1. Despite rapid advances over recent years, many of the molecular and cellular processes which underlie progressive loss of healthy physiology are poorly understood2. To gain a better insight into these processes we have created a single cell transcriptomic atlas across the life span of Mus musculus which includes data from 23 tissues and organs. We discovered cell-specific changes occurring across multiple cell types and organs, as well as age related changes in the cellular composition of different organs. Using single-cell transcriptomic data we were able to assess cell type specific manifestations of different hallmarks of aging, such as senescence3, genomic instability4 and changes in the organism’s immune system2. This Tabula Muris Senis provides a wealth of new molecular information about how the most significant hallmarks of aging are reflected in a broad range of tissues and cell types.

Footnotes

  • https://tabula-muris-senis.ds.czbiohub.org/

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted February 21, 2020.
Download PDF

Supplementary Material

Data/Code
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
A Single Cell Transcriptomic Atlas Characterizes Aging Tissues in the Mouse
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
A Single Cell Transcriptomic Atlas Characterizes Aging Tissues in the Mouse
The Tabula Muris Consortium, Angela Oliveira Pisco, Aaron McGeever, Nicholas Schaum, Jim Karkanias, Norma F Neff, Spyros Darmanis, Tony Wyss-Coray, Stephen R Quake
bioRxiv 661728; doi: https://doi.org/10.1101/661728
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
A Single Cell Transcriptomic Atlas Characterizes Aging Tissues in the Mouse
The Tabula Muris Consortium, Angela Oliveira Pisco, Aaron McGeever, Nicholas Schaum, Jim Karkanias, Norma F Neff, Spyros Darmanis, Tony Wyss-Coray, Stephen R Quake
bioRxiv 661728; doi: https://doi.org/10.1101/661728

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Cell Biology
Subject Areas
All Articles
  • Animal Behavior and Cognition (2653)
  • Biochemistry (5285)
  • Bioengineering (3696)
  • Bioinformatics (15823)
  • Biophysics (7279)
  • Cancer Biology (5633)
  • Cell Biology (8117)
  • Clinical Trials (138)
  • Developmental Biology (4781)
  • Ecology (7546)
  • Epidemiology (2059)
  • Evolutionary Biology (10604)
  • Genetics (7746)
  • Genomics (10163)
  • Immunology (5223)
  • Microbiology (13962)
  • Molecular Biology (5399)
  • Neuroscience (30873)
  • Paleontology (217)
  • Pathology (883)
  • Pharmacology and Toxicology (1527)
  • Physiology (2262)
  • Plant Biology (5035)
  • Scientific Communication and Education (1044)
  • Synthetic Biology (1399)
  • Systems Biology (4156)
  • Zoology (814)