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The role of the endoplasmic reticulum in in vivo cancer FDG kinetics

View ORCID ProfileMara Scussolini, Vanessa Cossu, Cecilia Marini, Gianmario Sambuceti, Giacomo Caviglia, View ORCID ProfileMichele Piana
doi: https://doi.org/10.1101/664417
Mara Scussolini
1Dipartimento di Matematica, Università di Genova, Genova, Italy
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Vanessa Cossu
2Dipartimento di Medicina Nucleare, IRCCS San Martino, Genova, Italy
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Cecilia Marini
3CNR – IBFM, Genova, Italy
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Gianmario Sambuceti
2Dipartimento di Medicina Nucleare, IRCCS San Martino, Genova, Italy
4Dipartimento di Scienze della Salute, Università di Genova, Genova, Italy
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Giacomo Caviglia
1Dipartimento di Matematica, Università di Genova, Genova, Italy
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Michele Piana
1Dipartimento di Matematica, Università di Genova, Genova, Italy
5CNR – SPIN Genova, Genova, Italy
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  • For correspondence: piana@dima.unige.it
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ABSTRACT

A very recent result obtained by means of an in vitro experiment with cancer cultured cells has configured the endoplasmic reticulum as the preferential site for the accumulation of 2-deoxy-2-[18F]fluoro-D-glucose (FDG). Such a result is coherent with cell biochemistry and is made more significant by the fact that reticular accumulation rate of FDG is dependent upon extracellular glucose availability. The objective of the present paper was to confirm this result in vivo, using small animal models of CT26 cancer tissues. Specifically, assuming that the endoplasmic reticulum plays a specific functional role in the framework of a three-compartment model for FDG kinetics, we are able to explain positron emission tomography dynamic data in a more reliable way than by means of a standard Sokoloff two-compartment system. This result is made more solid from a computational viewpoint by means of some identifiability considerations based on a mathematical analysis of the compartmental equations.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted June 08, 2019.
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The role of the endoplasmic reticulum in in vivo cancer FDG kinetics
Mara Scussolini, Vanessa Cossu, Cecilia Marini, Gianmario Sambuceti, Giacomo Caviglia, Michele Piana
bioRxiv 664417; doi: https://doi.org/10.1101/664417
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The role of the endoplasmic reticulum in in vivo cancer FDG kinetics
Mara Scussolini, Vanessa Cossu, Cecilia Marini, Gianmario Sambuceti, Giacomo Caviglia, Michele Piana
bioRxiv 664417; doi: https://doi.org/10.1101/664417

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