Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Guillain-Barre syndrome outbreak in Peru: Association with polymorphisms in IL-17, ICAM-1 and CD1

Luis Jaramillo-Valverde, Kelly S Levano, Isolina Villanueva, Meylin Hidalgo, Marco Cornejo, Pilar Mazzetti, Mario Cornejo-Olivas, Cesar Sanchez, Julio A Poterico, Julio Valdivia-Silva, Heinner Guio
doi: https://doi.org/10.1101/667154
Luis Jaramillo-Valverde
1INBIOMEDIC Research and Technological Center, Lima, Peru
2ALBIOTEC, Lima, Peru
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kelly S Levano
1INBIOMEDIC Research and Technological Center, Lima, Peru
2ALBIOTEC, Lima, Peru
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Isolina Villanueva
3Hospital Belén de Trujillo, La Libertad, Peru
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Meylin Hidalgo
3Hospital Belén de Trujillo, La Libertad, Peru
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marco Cornejo
3Hospital Belén de Trujillo, La Libertad, Peru
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pilar Mazzetti
4Neurogenetics Research Center, Instituto Nacional de Ciencias Neurológicas, Lima, Peru
5School of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mario Cornejo-Olivas
4Neurogenetics Research Center, Instituto Nacional de Ciencias Neurológicas, Lima, Peru
6Center for Global Health, Universidad Peruana Cayetano Heredia, Lima, Peru
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Cesar Sanchez
1INBIOMEDIC Research and Technological Center, Lima, Peru
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Julio A Poterico
7Servicio de Genética, Instituto Nacional de Salud del Niño San Borja (INSN-SB), Lima, Peru
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Julio Valdivia-Silva
8Department of Bioengineering and Chemical Engineering, Universidad de Ingenieria y Tecnologia - UTEC, Lima, Peru
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Heinner Guio
1INBIOMEDIC Research and Technological Center, Lima, Peru
2ALBIOTEC, Lima, Peru
9Universidad Científica del Sur, Lima, Peru
10Universidad de Huánuco, Huánuco, Peru
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: heinnerguio@gmail.com
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

SUMMARY

Guillain-Barre Syndrome (GBS) is considered a complex disorder with significant environmental effect and genetic susceptibility. Genetic polymorphisms in CD1E, CD1A, IL-17 and/or ICAM-1 genes had been proposed as susceptibility genetic variants for GBS mainly in Caucasian population. This study explores the association between selected polymorphisms in these genes and GBS susceptibility in confirmed GBS cases reported in mestizo population from northern Peru during the most recent GBS outbreak of May 2018. A total of 9 non-related cases and 11 controls were sequenced for the polymorphic regions of CD1A, CD1E, IL-17 and ICAM-1 genes. We found a significant protective association between heterozygous GA genotype in ICAM-1 gene (241Gly / Arg) and GBS (p <0.047). IL-17 was monomorphic in both controls and patients. No significant differences were found in the frequency of SNPs in CD1A and CD1E between the group with GBS patients and healthy controls. Further studies with larger sample size will be required to validate these findings.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted June 21, 2019.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Guillain-Barre syndrome outbreak in Peru: Association with polymorphisms in IL-17, ICAM-1 and CD1
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Guillain-Barre syndrome outbreak in Peru: Association with polymorphisms in IL-17, ICAM-1 and CD1
Luis Jaramillo-Valverde, Kelly S Levano, Isolina Villanueva, Meylin Hidalgo, Marco Cornejo, Pilar Mazzetti, Mario Cornejo-Olivas, Cesar Sanchez, Julio A Poterico, Julio Valdivia-Silva, Heinner Guio
bioRxiv 667154; doi: https://doi.org/10.1101/667154
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Guillain-Barre syndrome outbreak in Peru: Association with polymorphisms in IL-17, ICAM-1 and CD1
Luis Jaramillo-Valverde, Kelly S Levano, Isolina Villanueva, Meylin Hidalgo, Marco Cornejo, Pilar Mazzetti, Mario Cornejo-Olivas, Cesar Sanchez, Julio A Poterico, Julio Valdivia-Silva, Heinner Guio
bioRxiv 667154; doi: https://doi.org/10.1101/667154

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Molecular Biology
Subject Areas
All Articles
  • Animal Behavior and Cognition (3691)
  • Biochemistry (7800)
  • Bioengineering (5678)
  • Bioinformatics (21295)
  • Biophysics (10584)
  • Cancer Biology (8179)
  • Cell Biology (11948)
  • Clinical Trials (138)
  • Developmental Biology (6764)
  • Ecology (10401)
  • Epidemiology (2065)
  • Evolutionary Biology (13876)
  • Genetics (9709)
  • Genomics (13075)
  • Immunology (8151)
  • Microbiology (20022)
  • Molecular Biology (7859)
  • Neuroscience (43073)
  • Paleontology (321)
  • Pathology (1279)
  • Pharmacology and Toxicology (2261)
  • Physiology (3353)
  • Plant Biology (7232)
  • Scientific Communication and Education (1314)
  • Synthetic Biology (2008)
  • Systems Biology (5539)
  • Zoology (1128)