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Independent population coding of the present and the past in prefrontal cortex during learning

View ORCID ProfileSilvia Maggi, View ORCID ProfileMark D. Humphries
doi: https://doi.org/10.1101/668962
Silvia Maggi
1School of Psychology, University of Nottingham, Nottingham, UK
2Faculty of Biology, Medicine, and Health, University of Manchester, Manchester, UK
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  • ORCID record for Silvia Maggi
Mark D. Humphries
1School of Psychology, University of Nottingham, Nottingham, UK
2Faculty of Biology, Medicine, and Health, University of Manchester, Manchester, UK
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  • For correspondence: mark.humphries@nottingham.ac.uk
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Abstract

Medial prefrontal cortex (mPfC) plays a role in both immediate behaviour and short-term memory. Unknown is whether the present and past are represented simultaneously or separately in mPfC populations. To address this, we analysed mPfC population activity of rats learning rules in a Y-maze, with self-initiated choice trials followed by a self-paced return during the inter-trial interval. Joint mPfC population activity encoded solely present events and actions during the trial, with decoding of the past at chance; conversely, population encoding of the same features in the immediately following inter-trial interval was solely of the past. Despite being contiguous in time, each population orthogonally encoded the present and past of the same events and actions. Consequently, only the population code of the present during the trials, and not the past coding of the inter-trials intervals, was re-activated in subsequent sleep. Our results suggest that representations of the past and present in the mPfC independently contribute to the learning of a new rule.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted June 12, 2019.
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Independent population coding of the present and the past in prefrontal cortex during learning
Silvia Maggi, Mark D. Humphries
bioRxiv 668962; doi: https://doi.org/10.1101/668962
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Independent population coding of the present and the past in prefrontal cortex during learning
Silvia Maggi, Mark D. Humphries
bioRxiv 668962; doi: https://doi.org/10.1101/668962

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