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Genetic determinants of lipids and cardiovascular disease outcomes: a wide-angled Mendelian randomization investigation

View ORCID ProfileElias Allara, Gabriele Morani, Paul Carter, Apostolos Gkatzionis, Verena Zuber, Christopher N Foley, Jessica MB Rees, Amy M Mason, Steven Bell, Dipender Gill, Adam S Butterworth, Emanuele Di Angelantonio, James Peters, Stephen Burgess
doi: https://doi.org/10.1101/668970
Elias Allara
1MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
2National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK
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  • ORCID record for Elias Allara
Gabriele Morani
3Dipartimento di Scienze del Sistema Nervoso e del Comportamento, Università degli studi di Pavia, Pavia, Italy
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Paul Carter
1MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
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Apostolos Gkatzionis
4MRC Biostatistics Unit, University of Cambridge, Cambridge, UK
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Verena Zuber
4MRC Biostatistics Unit, University of Cambridge, Cambridge, UK
5Department of Epidemiology and Biostatistics, Imperial College London, London, UK
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Christopher N Foley
4MRC Biostatistics Unit, University of Cambridge, Cambridge, UK
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Jessica MB Rees
1MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
6Edinburgh Clinical Trials Unit, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK
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Amy M Mason
1MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
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Steven Bell
1MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
2National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK
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Dipender Gill
5Department of Epidemiology and Biostatistics, Imperial College London, London, UK
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Adam S Butterworth
1MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
2National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK
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Emanuele Di Angelantonio
1MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
2National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK
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James Peters
1MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
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Stephen Burgess
1MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
4MRC Biostatistics Unit, University of Cambridge, Cambridge, UK
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  • For correspondence: sb452@medschl.cam.ac.uk
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Article Information

doi 
https://doi.org/10.1101/668970
History 
  • June 14, 2019.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Elias Allara, MD1,2,
  2. Gabriele Morani, PhD3,
  3. Paul Carter, MB BS1,
  4. Apostolos Gkatzionis, PhD4,
  5. Verena Zuber, PhD4,5,
  6. Christopher N Foley, PhD4,
  7. Jessica MB Rees, MPhil1,6,
  8. Amy M Mason, PhD1,
  9. Steven Bell, PhD1,2,
  10. Dipender Gill, MD5,
  11. Adam S Butterworth, PhD1,2,
  12. Emanuele Di Angelantonio, FRCP1,2,
  13. James Peters, MB ChB PhD1 and
  14. Stephen Burgess, PhD1,4,*
  1. 1MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
  2. 2National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK
  3. 3Dipartimento di Scienze del Sistema Nervoso e del Comportamento, Università degli studi di Pavia, Pavia, Italy
  4. 4MRC Biostatistics Unit, University of Cambridge, Cambridge, UK
  5. 5Department of Epidemiology and Biostatistics, Imperial College London, London, UK
  6. 6Edinburgh Clinical Trials Unit, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK
  1. ↵*Corresponding author:
    Stephen Burgess (sb452{at}medschl.cam.ac.uk, +44 1223 768259)
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Posted June 14, 2019.
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Genetic determinants of lipids and cardiovascular disease outcomes: a wide-angled Mendelian randomization investigation
Elias Allara, Gabriele Morani, Paul Carter, Apostolos Gkatzionis, Verena Zuber, Christopher N Foley, Jessica MB Rees, Amy M Mason, Steven Bell, Dipender Gill, Adam S Butterworth, Emanuele Di Angelantonio, James Peters, Stephen Burgess
bioRxiv 668970; doi: https://doi.org/10.1101/668970
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Genetic determinants of lipids and cardiovascular disease outcomes: a wide-angled Mendelian randomization investigation
Elias Allara, Gabriele Morani, Paul Carter, Apostolos Gkatzionis, Verena Zuber, Christopher N Foley, Jessica MB Rees, Amy M Mason, Steven Bell, Dipender Gill, Adam S Butterworth, Emanuele Di Angelantonio, James Peters, Stephen Burgess
bioRxiv 668970; doi: https://doi.org/10.1101/668970

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