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Stress Resets Transgenerational Small RNA Inheritance

Leah Houri-Ze’evi, Guy Teichman, Hila Gingold, Oded Rechavi
doi: https://doi.org/10.1101/669051
Leah Houri-Ze’evi
1Department of Neurobiology, Wise Faculty of Life Sciences & Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel 69978.
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  • For correspondence: odedrechavi@gmail.com leah.houri@gmail.com guy.teichman@gmail.com
Guy Teichman
1Department of Neurobiology, Wise Faculty of Life Sciences & Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel 69978.
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  • For correspondence: odedrechavi@gmail.com leah.houri@gmail.com guy.teichman@gmail.com
Hila Gingold
1Department of Neurobiology, Wise Faculty of Life Sciences & Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel 69978.
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Oded Rechavi
1Department of Neurobiology, Wise Faculty of Life Sciences & Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel 69978.
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  • For correspondence: odedrechavi@gmail.com leah.houri@gmail.com guy.teichman@gmail.com
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Abstract

Transgenerational inheritance of small RNAs is challenging basic concepts of heredity and achieving control over such responses is of great interest. In C. elegans nematodes, small RNAs are transmitted across generations to establish a transgenerational memory trace of ancestral environments and distinguish self from non-self genes. Inheritance of small RNAs is regulated by dedicated machinery and carryover of aberrant heritable small RNA responses was shown to be maladaptive and to induce sterility. Here we show that various types of stress (starvation, high temperatures, and high osmolarity) but not non-stressful changes in cultivation conditions, lead to resetting of small RNA inheritance. We found that stress leads to a genome-wide reduction in heritable small RNA levels and that mutants defective in different stress pathways exhibit irregular RNAi inheritance dynamics. Moreover, we discovered that resetting of heritable RNAi is orchestrated by MAPK pathway factors, the transcription factor SKN-1, and the MET-2 methyltransferase. Termination of small RNA inheritance, and the fact that this process depends on stress, could protect from run-on of environment-irrelevant heritable gene regulation.

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Posted June 13, 2019.
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Stress Resets Transgenerational Small RNA Inheritance
Leah Houri-Ze’evi, Guy Teichman, Hila Gingold, Oded Rechavi
bioRxiv 669051; doi: https://doi.org/10.1101/669051
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Stress Resets Transgenerational Small RNA Inheritance
Leah Houri-Ze’evi, Guy Teichman, Hila Gingold, Oded Rechavi
bioRxiv 669051; doi: https://doi.org/10.1101/669051

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