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Cohort profile: The LipidCardio Study - Role of Lipoproteins in Cardiovascular Disease

Maximilian König, Samita Joshi, David M. Leistner, Ulf Landmesser, David Sinning, Elisabeth Steinhagen-Thiessen, Ilja Demuth
doi: https://doi.org/10.1101/669150
Maximilian König
Medizinische Klinik mit Schwerpunkt Nephrologie und Intensivmedizin, Charité-Universitätsmedizin BerlinCharité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center, Germany
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Samita Joshi
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center, Germany
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David M. Leistner
Medizinische Klinik für Kardiologie, Campus Benjamin Franklin (CBF), Charité-Universitätsmedizin Berlin
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Ulf Landmesser
Medizinische Klinik für Kardiologie, Campus Benjamin Franklin (CBF), Charité-Universitätsmedizin BerlinBerlin Institute of Health (BIH); Deutsches Zentrum für Herzkreislaufforschung (DZHK), partner site Berlin
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David Sinning
Medizinische Klinik für Kardiologie, Campus Benjamin Franklin (CBF), Charité-Universitätsmedizin Berlin
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Elisabeth Steinhagen-Thiessen
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center, Germany
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Ilja Demuth
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center, GermanyBerlin-Brandenburg Center for Regenerative Medicine (BCRT), Charité University Medicine Berlin, Germany
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  • For correspondence: ilja.demuth@charite.de
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Abstract

Purpose The LipidCardio Study was established for in-depth analyses of cardiovascular risk factors, providing well-defined cardiovascular and metabolic phenotypes. Particularly the role of lipoproteins in the pathobiological process and treatment of cardiovascular disease will be a main focus.

Participants 1.005 individuals aged 21 years and older undergoing cardiac catheterization during 17 months at a tertiary academic cardiology center were enrolled. The baseline data set contains detailed phenotyping, broad biochemical parameters, genetic data, but also standardized personal and family history, a screening test for cognitive impairment, pulse wave analysis and measurements of hand grip strength, amongst others. Blood samples were stored in a biobank for future analyses.

Findings to date The mean age of the participants at enrolment was 70.9±11.1 years (70% male). Coronary angiography provided evidence of obstructive coronary artery disease (CAD) in 69.9% of participants. Those with evidence of CAD were significantly more likely to be male, inactive, diabetic and with a family history of cardiovascular disease than participants without CAD.

20% of patients had lipoprotein(a) [Lp(a)] concentrations above 106.9 nmol/L (fifth quintile). These patients had significantly increased odds of obstructive CAD compared to participants in quintiles 1-4 (OR 1.70, 95% CI 1.17 to 2.48, p=0.005). There was reasonable evidence that with increasing severity of CAD the odds of having elevated Lp(a) increased. We were able to replicate the established strong association between specified single nucleotide polymorphisms (SNPs) in the LPA gene (rs10455872, rs3798220 and rs186696265) and the APOE gene (rs7412), and the concentration of Lp(a), validating our phenotype database and biobank.

Future plans Mortality information will be obtained in two-year intervals. Follow-up phone interviews will be conducted at 3, and 6 years after enrolment. We seek to cooperate with other researchers in the field, e.g. by sharing data and biobank samples.

Registration not applicable, purely observational study

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Posted June 14, 2019.
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Cohort profile: The LipidCardio Study - Role of Lipoproteins in Cardiovascular Disease
Maximilian König, Samita Joshi, David M. Leistner, Ulf Landmesser, David Sinning, Elisabeth Steinhagen-Thiessen, Ilja Demuth
bioRxiv 669150; doi: https://doi.org/10.1101/669150
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Cohort profile: The LipidCardio Study - Role of Lipoproteins in Cardiovascular Disease
Maximilian König, Samita Joshi, David M. Leistner, Ulf Landmesser, David Sinning, Elisabeth Steinhagen-Thiessen, Ilja Demuth
bioRxiv 669150; doi: https://doi.org/10.1101/669150

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