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Accurate estimation of cell composition in bulk expression through robust integration of single-cell information

Brandon Jew, Marcus Alvarez, Elior Rahmani, Zong Miao, Arthur Ko, Jae Hoon Sul, Kirsi H. Pietiläinen, Päivi Pajukanta, Eran Halperin
doi: https://doi.org/10.1101/669911
Brandon Jew
1Bioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA, 90095
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Marcus Alvarez
2Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA, 90095
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Elior Rahmani
3Computer Science Department in the School of Engineering, UCLA, Los Angeles, CA, USA, 90095
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Zong Miao
1Bioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA, 90095
2Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA, 90095
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Arthur Ko
2Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA, 90095
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Jae Hoon Sul
1Bioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA, 90095
4Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA, USA 90095
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Kirsi H. Pietiläinen
5Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland, 00014
6Obesity Center, Endocrinology, Abdominal Center, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland, 00260
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Päivi Pajukanta
1Bioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA, 90095
2Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA, 90095
7Institute for Precision Health, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA, 90095
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  • For correspondence: ehalperin@cs.ucla.edu
Eran Halperin
1Bioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA, 90095
2Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA, 90095
3Computer Science Department in the School of Engineering, UCLA, Los Angeles, CA, USA, 90095
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  • For correspondence: ehalperin@cs.ucla.edu
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Article Information

doi 
https://doi.org/10.1101/669911
History 
  • June 15, 2019.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.

Author Information

  1. Brandon Jew1,*,
  2. Marcus Alvarez2,*,
  3. Elior Rahmani3,
  4. Zong Miao1,2,
  5. Arthur Ko2,
  6. Jae Hoon Sul1,4,
  7. Kirsi H. Pietiläinen5,6,
  8. Päivi Pajukanta1,2,7,** and
  9. Eran Halperin1,2,3,**
  1. 1Bioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA, 90095
  2. 2Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA, 90095
  3. 3Computer Science Department in the School of Engineering, UCLA, Los Angeles, CA, USA, 90095
  4. 4Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA, USA 90095
  5. 5Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland, 00014
  6. 6Obesity Center, Endocrinology, Abdominal Center, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland, 00260
  7. 7Institute for Precision Health, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA, 90095
  1. ↵**Co-corresponding authors; email: ehalperin{at}cs.ucla.edu
  1. ↵* These authors contributed equally to this work.

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Posted June 15, 2019.
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Accurate estimation of cell composition in bulk expression through robust integration of single-cell information
Brandon Jew, Marcus Alvarez, Elior Rahmani, Zong Miao, Arthur Ko, Jae Hoon Sul, Kirsi H. Pietiläinen, Päivi Pajukanta, Eran Halperin
bioRxiv 669911; doi: https://doi.org/10.1101/669911
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Accurate estimation of cell composition in bulk expression through robust integration of single-cell information
Brandon Jew, Marcus Alvarez, Elior Rahmani, Zong Miao, Arthur Ko, Jae Hoon Sul, Kirsi H. Pietiläinen, Päivi Pajukanta, Eran Halperin
bioRxiv 669911; doi: https://doi.org/10.1101/669911

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