New Results
Predicting Functional Effects of Missense Variants in Voltage-Gated Sodium and Calcium Channels
Henrike O. Heyne, David Baez-Nieto, Sumaiya Iqbal, Duncan Palmer, Andreas Brunklaus, the Epi25 Collaborative, Katrine M. Johannesen, Stephan Lauxmann, Johannes R. Lemke, Rikke S. Møller, Eduardo Pérez-Palma, Ute Scholl, Steffen Syrbe, Holger Lerche, Patrick May, Dennis Lal, Arthur J. Campbell, Jen Pan, Hao-Ran Wang, Mark J. Daly
doi: https://doi.org/10.1101/671453
Henrike O. Heyne
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
2Program in Medical and Population Genetics, Broad Institute of MIT & Harvard, Cambridge, Massachusetts, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT & Harvard, Cambridge, MA, USA
David Baez-Nieto
3Stanley Center for Psychiatric Research, Broad Institute of MIT & Harvard, Cambridge, MA, USA
Sumaiya Iqbal
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
2Program in Medical and Population Genetics, Broad Institute of MIT & Harvard, Cambridge, Massachusetts, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT & Harvard, Cambridge, MA, USA
Duncan Palmer
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
2Program in Medical and Population Genetics, Broad Institute of MIT & Harvard, Cambridge, Massachusetts, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT & Harvard, Cambridge, MA, USA
Andreas Brunklaus
4The Paediatric Neurosciences Research Group, Royal Hospital for Sick Children, Glasgow, UK
5School of Medicine, University of Glasgow, Glasgow, UK
Katrine M. Johannesen
6Department of Epilepsy Genetics and Personalized Treatment, The Danish Epilepsy Centre,, Dianalund, Denmark
7Department of Regional Health Research, University of Southern Denmark, Odense, Denmark
Stephan Lauxmann
13Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
Johannes R. Lemke
8Institute of Human Genetics, University of Leipzig Medical Center, Leipzig, Germany
Rikke S. Møller
6Department of Epilepsy Genetics and Personalized Treatment, The Danish Epilepsy Centre,, Dianalund, Denmark
7Department of Regional Health Research, University of Southern Denmark, Odense, Denmark
Eduardo Pérez-Palma
9Cologne Center for Genomics (CCG), University of Cologne, Germany
Ute Scholl
10Department of Nephrology and Medical Intensive Care, Berlin Institute of Health (BIH) and Charité – Universitätsmedizin Berlin, Berlin, Germany
11Berlin Institute of Health Center for Regenerative Therapies, Charité – Universitätsmedizin Berlin, Berlin, Germany
Steffen Syrbe
12Division of Child Neurology and Metabolic Medicine, Center for Paediatrics and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany
Holger Lerche
13Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
Patrick May
14Luxembourg Centre for Systems Biomedicine, Esch-sur-Alzette, University of Luxembourg, Luxembourg
Dennis Lal
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
2Program in Medical and Population Genetics, Broad Institute of MIT & Harvard, Cambridge, Massachusetts, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT & Harvard, Cambridge, MA, USA
9Cologne Center for Genomics (CCG), University of Cologne, Germany
15Genomic Medicine Institute, Lerner Research Institute Cleveland Clinic, OH, US
16Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, US
Arthur J. Campbell
3Stanley Center for Psychiatric Research, Broad Institute of MIT & Harvard, Cambridge, MA, USA
Jen Pan
3Stanley Center for Psychiatric Research, Broad Institute of MIT & Harvard, Cambridge, MA, USA
Hao-Ran Wang
3Stanley Center for Psychiatric Research, Broad Institute of MIT & Harvard, Cambridge, MA, USA
Mark J. Daly
1Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
2Program in Medical and Population Genetics, Broad Institute of MIT & Harvard, Cambridge, Massachusetts, USA
3Stanley Center for Psychiatric Research, Broad Institute of MIT & Harvard, Cambridge, MA, USA
17Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
Posted June 14, 2019.
Predicting Functional Effects of Missense Variants in Voltage-Gated Sodium and Calcium Channels
Henrike O. Heyne, David Baez-Nieto, Sumaiya Iqbal, Duncan Palmer, Andreas Brunklaus, the Epi25 Collaborative, Katrine M. Johannesen, Stephan Lauxmann, Johannes R. Lemke, Rikke S. Møller, Eduardo Pérez-Palma, Ute Scholl, Steffen Syrbe, Holger Lerche, Patrick May, Dennis Lal, Arthur J. Campbell, Jen Pan, Hao-Ran Wang, Mark J. Daly
bioRxiv 671453; doi: https://doi.org/10.1101/671453
Predicting Functional Effects of Missense Variants in Voltage-Gated Sodium and Calcium Channels
Henrike O. Heyne, David Baez-Nieto, Sumaiya Iqbal, Duncan Palmer, Andreas Brunklaus, the Epi25 Collaborative, Katrine M. Johannesen, Stephan Lauxmann, Johannes R. Lemke, Rikke S. Møller, Eduardo Pérez-Palma, Ute Scholl, Steffen Syrbe, Holger Lerche, Patrick May, Dennis Lal, Arthur J. Campbell, Jen Pan, Hao-Ran Wang, Mark J. Daly
bioRxiv 671453; doi: https://doi.org/10.1101/671453
Subject Area
Subject Areas
- Biochemistry (11739)
- Bioengineering (8750)
- Bioinformatics (29189)
- Biophysics (14967)
- Cancer Biology (12093)
- Cell Biology (17409)
- Clinical Trials (138)
- Developmental Biology (9419)
- Ecology (14178)
- Epidemiology (2067)
- Evolutionary Biology (18301)
- Genetics (12238)
- Genomics (16797)
- Immunology (11865)
- Microbiology (28068)
- Molecular Biology (11583)
- Neuroscience (60953)
- Paleontology (451)
- Pathology (1870)
- Pharmacology and Toxicology (3238)
- Physiology (4957)
- Plant Biology (10425)
- Synthetic Biology (2884)
- Systems Biology (7338)
- Zoology (1651)