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Distinct roles of parvalbumin and somatostatin interneurons in the synchronization of spike-times in the neocortex

Hyun Jae Jang, Hyowon Chung, James M. Rowland, Blake A. Richards, Michael M. Kohl, Jeehyun Kwag
doi: https://doi.org/10.1101/671743
Hyun Jae Jang
1Department of Brain and Cognitive Engineering, Korea University, Seoul, Korea
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Hyowon Chung
1Department of Brain and Cognitive Engineering, Korea University, Seoul, Korea
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James M. Rowland
2Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
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Blake A. Richards
3Department of Biological Sciences, University of Toronto Scarborough, Toronto, Canada
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Michael M. Kohl
2Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
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Jeehyun Kwag
1Department of Brain and Cognitive Engineering, Korea University, Seoul, Korea
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  • For correspondence: jkwag@korea.ac.kr
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Abstract

Synchronization of precise spike-times across multiple neurons carries information about sensory stimuli. Inhibitory interneurons are suggested to promote this synchronization, but it is unclear whether distinct interneuron subtypes provide different contributions. To test this, we examined single-unit recordings from barrel cortex in vivo and used optogenetics to determine the contribution of two classes of inhibitory interneurons: parvalbumin (PV)- and somatostatin (SST)-positive interneurons to spike-timing synchronization across cortical layers. We found that PV interneurons preferentially promote the synchronization of spike-times when instantaneous firing-rates are low (<12 Hz), whereas SST interneurons preferentially promote the synchronization of spike-times when instantaneous firing-rates are high (>12 Hz). Furthermore, using a computational model, we demonstrate that these effects can be explained by PV and SST interneurons having preferential contribution to feedforward and feedback inhibition, respectively. Our findings demonstrate that distinct subtypes of inhibitory interneurons have frequency-selective roles in spatio-temporal synchronization of precise spike-times.

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Posted June 15, 2019.
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Distinct roles of parvalbumin and somatostatin interneurons in the synchronization of spike-times in the neocortex
Hyun Jae Jang, Hyowon Chung, James M. Rowland, Blake A. Richards, Michael M. Kohl, Jeehyun Kwag
bioRxiv 671743; doi: https://doi.org/10.1101/671743
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Distinct roles of parvalbumin and somatostatin interneurons in the synchronization of spike-times in the neocortex
Hyun Jae Jang, Hyowon Chung, James M. Rowland, Blake A. Richards, Michael M. Kohl, Jeehyun Kwag
bioRxiv 671743; doi: https://doi.org/10.1101/671743

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