Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Impact of white spotting alleles, including W20, on phenotype in the American Paint Horse

Samantha A. Brooks, Katelyn M. Palermo, Alisha Kahn, Jessica Hein
doi: https://doi.org/10.1101/678052
Samantha A. Brooks
*University of Florida Department of Animal Sciences, UF Genetics Institute, Gainesville FL, 32611-0910
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: samantha.brooks@ufl.edu
Katelyn M. Palermo
*University of Florida Department of Animal Sciences, UF Genetics Institute, Gainesville FL, 32611-0910
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alisha Kahn
*University of Florida Department of Animal Sciences, UF Genetics Institute, Gainesville FL, 32611-0910
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jessica Hein
#American Paint Horse Association, Fort Worth TX, 76161-0023
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

The American Paint Horse Association (APHA) officially records pedigree and performance information for their breed; these registered stock-type horses are valued for utility in work on the farm and ranch and as pleasure horses. As the name of the breed implies, the breed is also valued for attractive white spotting patterns on the coat. Current APHA procedures utilize visual inspections of photographs to determine if white spotting phenotypes exceed threshold anatomical landmarks considered by the association as characteristic of desirable patterns. Horses with sufficient white patterning enter the “Regular” registry, rather than the “Solid Paint-Bred” division. Genetic studies have now defined causative sequence variants for 35 alleles likely contributing to white spotting phenotypes in the horse. Here, the allele frequency was calculated for nine white spotting alleles commonly found in the American Paint horse breed using a sample of 1,065 APHA registered animals. Epistatic interactions were documented among five spotting loci, and with the MC1R and ASIP genes controlling black and red pigment production. The W20 allele within the KIT gene, in the absence of other spotting loci, was strongly associated with the APHA-defined white spotting phenotype (p = 1.86 x10−18), refuting advertisements reporting that W20 acts only as a modifier of other white spotting patterns. An empirical definition of the action of these loci on the desired APHA-defined white spotting phenotype will allow for a more accurate application of genome-assisted selection in this breed, providing breeders with a powerful tool to increase the marketability of their horses.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted June 21, 2019.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Impact of white spotting alleles, including W20, on phenotype in the American Paint Horse
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Impact of white spotting alleles, including W20, on phenotype in the American Paint Horse
Samantha A. Brooks, Katelyn M. Palermo, Alisha Kahn, Jessica Hein
bioRxiv 678052; doi: https://doi.org/10.1101/678052
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Impact of white spotting alleles, including W20, on phenotype in the American Paint Horse
Samantha A. Brooks, Katelyn M. Palermo, Alisha Kahn, Jessica Hein
bioRxiv 678052; doi: https://doi.org/10.1101/678052

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Genetics
Subject Areas
All Articles
  • Animal Behavior and Cognition (3573)
  • Biochemistry (7517)
  • Bioengineering (5479)
  • Bioinformatics (20675)
  • Biophysics (10257)
  • Cancer Biology (7931)
  • Cell Biology (11578)
  • Clinical Trials (138)
  • Developmental Biology (6563)
  • Ecology (10135)
  • Epidemiology (2065)
  • Evolutionary Biology (13537)
  • Genetics (9497)
  • Genomics (12788)
  • Immunology (7870)
  • Microbiology (19451)
  • Molecular Biology (7613)
  • Neuroscience (41871)
  • Paleontology (306)
  • Pathology (1252)
  • Pharmacology and Toxicology (2179)
  • Physiology (3249)
  • Plant Biology (7005)
  • Scientific Communication and Education (1291)
  • Synthetic Biology (1942)
  • Systems Biology (5405)
  • Zoology (1107)