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High precision coding in mouse visual cortex

View ORCID ProfileCarsen Stringer, View ORCID ProfileMichalis Michaelos, Marius Pachitariu
doi: https://doi.org/10.1101/679324
Carsen Stringer
1HHMI Janelia Research Campus, Ashburn, VA, USA
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  • For correspondence: stringerc@janelia.hhmi.org pachitarium@janelia.hhmi.org
Michalis Michaelos
1HHMI Janelia Research Campus, Ashburn, VA, USA
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Marius Pachitariu
1HHMI Janelia Research Campus, Ashburn, VA, USA
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  • For correspondence: stringerc@janelia.hhmi.org pachitarium@janelia.hhmi.org
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ABSTRACT

Single neurons in visual cortex provide unreliable measurements of visual features due to their high trial-to-trial variability. It is not known if this “noise” extends its effects over large neural populations to impair the global encoding of sensory stimuli. We recorded simultaneously from ∼20,000 neurons in mouse visual cortex and found that the neural population had discrimination thresholds of 0.3° in an orientation decoding task. These thresholds are ∼100 times smaller than those reported behaviorally in mice. The discrepancy between neural and behavioral discrimination could not be explained by the types of stimuli we used, by behavioral states or by the sequential nature of trial-by-trial perceptual learning tasks. These results imply that the limits of sensory perception in mice are not set by neural noise in sensory cortex, but by the limitations of downstream decoders.

Footnotes

  • https://figshare.com/articles/Recordings_of_20_000_neurons_from_V1_in_response_to_oriented_stimuli/8279387

  • https://github.com/MouseLand/stringer-et-al-2019

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted June 21, 2019.
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High precision coding in mouse visual cortex
Carsen Stringer, Michalis Michaelos, Marius Pachitariu
bioRxiv 679324; doi: https://doi.org/10.1101/679324
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High precision coding in mouse visual cortex
Carsen Stringer, Michalis Michaelos, Marius Pachitariu
bioRxiv 679324; doi: https://doi.org/10.1101/679324

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