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Brain state stability during working memory is explained by network control theory, modulated by dopamine D1/D2 receptor function, and diminished in schizophrenia
Urs Braun, Anais Harneit, Giulio Pergola, Tommaso Menara, Axel Schaefer, Richard F. Betzel, Zhenxiang Zang, Janina I. Schweiger, Kristina Schwarz, Junfang Chen, Giuseppe Blasi, Alessandro Bertolino, Daniel Durstewitz, Fabio Pasqualetti, Emanuel Schwarz, Andreas Meyer-Lindenberg, Danielle S. Bassett, Heike Tost
doi: https://doi.org/10.1101/679670
Urs Braun
1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
2Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA
Anais Harneit
1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Giulio Pergola
3Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, 70124 Bari, Italy
Tommaso Menara
4Mechanical Engineering Department, University of California at Riverside, Riverside, CA, USA
Axel Schaefer
5Bender Institute of Neuroimaging, Justus Liebig University Giessen & Center for Mind, Brain and Behavior, University of Marburg and Justus Liebig University Giessen, Giessen, Germany
Richard F. Betzel
6Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA
Zhenxiang Zang
1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Janina I. Schweiger
1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Kristina Schwarz
1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Junfang Chen
1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Giuseppe Blasi
3Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, 70124 Bari, Italy
Alessandro Bertolino
3Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, 70124 Bari, Italy
Daniel Durstewitz
7Department of Theoretical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany
Fabio Pasqualetti
4Mechanical Engineering Department, University of California at Riverside, Riverside, CA, USA
Emanuel Schwarz
1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Andreas Meyer-Lindenberg
1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Danielle S. Bassett
2Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA
8Department of Psychiatry, Department of Neurology, Department of Physics & Astronomy, and Department of Electrical & Systems Engineering, University of Pennsylvania, Philadelphia, PA, USA
Heike Tost
1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

Abstract
Dynamical brain state transitions are critical for flexible working memory but the network mechanisms are incompletely understood. Here, we show that working memory entails brain-wide switching between activity states. The stability of states relates to dopamine D1 receptor gene expression while state transitions are influenced by D2 receptor expression and pharmacological modulation. Schizophrenia patients show altered network control properties, including a more diverse energy landscape and decreased stability of working memory representations.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Posted June 23, 2019.
Brain state stability during working memory is explained by network control theory, modulated by dopamine D1/D2 receptor function, and diminished in schizophrenia
Urs Braun, Anais Harneit, Giulio Pergola, Tommaso Menara, Axel Schaefer, Richard F. Betzel, Zhenxiang Zang, Janina I. Schweiger, Kristina Schwarz, Junfang Chen, Giuseppe Blasi, Alessandro Bertolino, Daniel Durstewitz, Fabio Pasqualetti, Emanuel Schwarz, Andreas Meyer-Lindenberg, Danielle S. Bassett, Heike Tost
bioRxiv 679670; doi: https://doi.org/10.1101/679670
Brain state stability during working memory is explained by network control theory, modulated by dopamine D1/D2 receptor function, and diminished in schizophrenia
Urs Braun, Anais Harneit, Giulio Pergola, Tommaso Menara, Axel Schaefer, Richard F. Betzel, Zhenxiang Zang, Janina I. Schweiger, Kristina Schwarz, Junfang Chen, Giuseppe Blasi, Alessandro Bertolino, Daniel Durstewitz, Fabio Pasqualetti, Emanuel Schwarz, Andreas Meyer-Lindenberg, Danielle S. Bassett, Heike Tost
bioRxiv 679670; doi: https://doi.org/10.1101/679670
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