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Brain state stability during working memory is explained by network control theory, modulated by dopamine D1/D2 receptor function, and diminished in schizophrenia

Urs Braun, Anais Harneit, Giulio Pergola, Tommaso Menara, Axel Schaefer, Richard F. Betzel, Zhenxiang Zang, Janina I. Schweiger, Kristina Schwarz, Junfang Chen, Giuseppe Blasi, Alessandro Bertolino, Daniel Durstewitz, Fabio Pasqualetti, Emanuel Schwarz, Andreas Meyer-Lindenberg, Danielle S. Bassett, Heike Tost
doi: https://doi.org/10.1101/679670
Urs Braun
1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
2Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA
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  • For correspondence: urs.braun@zi-mannheim.de
Anais Harneit
1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
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Giulio Pergola
3Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, 70124 Bari, Italy
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Tommaso Menara
4Mechanical Engineering Department, University of California at Riverside, Riverside, CA, USA
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Axel Schaefer
5Bender Institute of Neuroimaging, Justus Liebig University Giessen & Center for Mind, Brain and Behavior, University of Marburg and Justus Liebig University Giessen, Giessen, Germany
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Richard F. Betzel
6Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA
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Zhenxiang Zang
1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
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Janina I. Schweiger
1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
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Kristina Schwarz
1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
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Junfang Chen
1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
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Giuseppe Blasi
3Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, 70124 Bari, Italy
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Alessandro Bertolino
3Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, 70124 Bari, Italy
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Daniel Durstewitz
7Department of Theoretical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany
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Fabio Pasqualetti
4Mechanical Engineering Department, University of California at Riverside, Riverside, CA, USA
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Emanuel Schwarz
1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
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Andreas Meyer-Lindenberg
1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
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Danielle S. Bassett
2Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA
8Department of Psychiatry, Department of Neurology, Department of Physics & Astronomy, and Department of Electrical & Systems Engineering, University of Pennsylvania, Philadelphia, PA, USA
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Heike Tost
1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
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Abstract

Dynamical brain state transitions are critical for flexible working memory but the network mechanisms are incompletely understood. Here, we show that working memory entails brain-wide switching between activity states. The stability of states relates to dopamine D1 receptor gene expression while state transitions are influenced by D2 receptor expression and pharmacological modulation. Schizophrenia patients show altered network control properties, including a more diverse energy landscape and decreased stability of working memory representations.

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Posted June 23, 2019.
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Brain state stability during working memory is explained by network control theory, modulated by dopamine D1/D2 receptor function, and diminished in schizophrenia
Urs Braun, Anais Harneit, Giulio Pergola, Tommaso Menara, Axel Schaefer, Richard F. Betzel, Zhenxiang Zang, Janina I. Schweiger, Kristina Schwarz, Junfang Chen, Giuseppe Blasi, Alessandro Bertolino, Daniel Durstewitz, Fabio Pasqualetti, Emanuel Schwarz, Andreas Meyer-Lindenberg, Danielle S. Bassett, Heike Tost
bioRxiv 679670; doi: https://doi.org/10.1101/679670
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Brain state stability during working memory is explained by network control theory, modulated by dopamine D1/D2 receptor function, and diminished in schizophrenia
Urs Braun, Anais Harneit, Giulio Pergola, Tommaso Menara, Axel Schaefer, Richard F. Betzel, Zhenxiang Zang, Janina I. Schweiger, Kristina Schwarz, Junfang Chen, Giuseppe Blasi, Alessandro Bertolino, Daniel Durstewitz, Fabio Pasqualetti, Emanuel Schwarz, Andreas Meyer-Lindenberg, Danielle S. Bassett, Heike Tost
bioRxiv 679670; doi: https://doi.org/10.1101/679670

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