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No evidence for motor recovery-related cortical reorganization after stroke using resting-state fMRI

View ORCID ProfileMeret Branscheidt, Naveed Ejaz, Jing Xu, Mario Widmer, Michelle D. Harran, Juan Camillo Cortés, Tomoko Kitago, Pablo Celnik, Carlos Hernandez-Castillo, View ORCID ProfileJörn Diedrichsen, Andreas Luft, View ORCID ProfileJohn W. Krakauer
doi: https://doi.org/10.1101/681320
Meret Branscheidt
1Brain Physiology & Stimulation Laboratory, Department of Physical Medicine & Rehabilitation, Johns Hopkins University, Baltimore, Maryland, USA
2Department of Neurology, University Hospital Zurich, Zürich, Switzerland
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  • For correspondence: meret.branscheidt@usz.ch
Naveed Ejaz
3Brain and Mind Institute, Western University, London, Ontario, Canada
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Jing Xu
4Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA
5Johns Hopkins University, Malone Center for Engineering in Healthcare, Baltimore, MD, USA
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Mario Widmer
2Department of Neurology, University Hospital Zurich, Zürich, Switzerland
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Michelle D. Harran
4Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA
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Juan Camillo Cortés
7Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
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Tomoko Kitago
8Burke Neurological Institute and Weill Cornell Medicine
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Pablo Celnik
1Brain Physiology & Stimulation Laboratory, Department of Physical Medicine & Rehabilitation, Johns Hopkins University, Baltimore, Maryland, USA
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Carlos Hernandez-Castillo
3Brain and Mind Institute, Western University, London, Ontario, Canada
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Jörn Diedrichsen
3Brain and Mind Institute, Western University, London, Ontario, Canada
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Andreas Luft
2Department of Neurology, University Hospital Zurich, Zürich, Switzerland
6cereneo center for neurology and rehabilitation, Vitznau, CH
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John W. Krakauer
4Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA
5Johns Hopkins University, Malone Center for Engineering in Healthcare, Baltimore, MD, USA
7Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
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Abstract

Cortical reorganization has been suggested as mechanism for recovery after stroke. It has been proposed that a form of cortical reorganization (changes in functional connectivity between brain areas) can be assessed with resting-state fMRI. Here we report the largest longitudinal data-set in terms of overall sessions in 19 patients with subcortical stroke and 11 controls. Patients were imaged up to 5 times over one year. We found no evidence for post-stroke cortical reorganization despite substantial behavioral recovery. These results could be construed as questioning the value of resting-state imaging. Here we argue instead that they are consistent with other emerging reasons to challenge the idea of motor recovery-related cortical reorganization post-stroke when conceived as changes in connectivity between cortical areas.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted June 26, 2019.
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No evidence for motor recovery-related cortical reorganization after stroke using resting-state fMRI
Meret Branscheidt, Naveed Ejaz, Jing Xu, Mario Widmer, Michelle D. Harran, Juan Camillo Cortés, Tomoko Kitago, Pablo Celnik, Carlos Hernandez-Castillo, Jörn Diedrichsen, Andreas Luft, John W. Krakauer
bioRxiv 681320; doi: https://doi.org/10.1101/681320
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No evidence for motor recovery-related cortical reorganization after stroke using resting-state fMRI
Meret Branscheidt, Naveed Ejaz, Jing Xu, Mario Widmer, Michelle D. Harran, Juan Camillo Cortés, Tomoko Kitago, Pablo Celnik, Carlos Hernandez-Castillo, Jörn Diedrichsen, Andreas Luft, John W. Krakauer
bioRxiv 681320; doi: https://doi.org/10.1101/681320

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