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Potential antigenic mismatch of the H3N2 component of the 2019 Southern Hemisphere influenza vaccine

Sigrid Gouma, Madison Weirick, View ORCID ProfileScott E. Hensley
doi: https://doi.org/10.1101/681734
Sigrid Gouma
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
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Madison Weirick
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
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Scott E. Hensley
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
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  • ORCID record for Scott E. Hensley
  • For correspondence: hensley@pennmedicine.upenn.edu
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Abstract

Here, we find that the egg-adapted H3N2 component of the 2019 Southern Hemisphere influenza vaccine elicits an antibody response in ferrets that is highly focused on antigenic site A of hemagglutinin. This is potentially problematic since most H3N2 viruses currently circulating in the Southern Hemisphere possess antigenic site A substitutions.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted June 24, 2019.
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Potential antigenic mismatch of the H3N2 component of the 2019 Southern Hemisphere influenza vaccine
Sigrid Gouma, Madison Weirick, Scott E. Hensley
bioRxiv 681734; doi: https://doi.org/10.1101/681734
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Potential antigenic mismatch of the H3N2 component of the 2019 Southern Hemisphere influenza vaccine
Sigrid Gouma, Madison Weirick, Scott E. Hensley
bioRxiv 681734; doi: https://doi.org/10.1101/681734

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