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Recovery of glutamatergic and GABAergic protein expression in visual cortex after monocular deprivation

View ORCID ProfileJustin L. Balsor, View ORCID ProfileDavid G. Jones, View ORCID ProfileKathryn M. Murphy
doi: https://doi.org/10.1101/684191
Justin L. Balsor
1McMaster Integrative Neuroscience Discovery and Study (MiNDS) Program, McMaster University, Hamilton, ON, L8S 4K1, Canada
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  • ORCID record for Justin L. Balsor
David G. Jones
2Pairwise Affinity Inc, Dundas, ON, L9H 2R9, Canada
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Kathryn M. Murphy
1McMaster Integrative Neuroscience Discovery and Study (MiNDS) Program, McMaster University, Hamilton, ON, L8S 4K1, Canada
3Department of Psychology, Neuroscience & Behavior, McMaster University, Hamilton, ON, L8S 4K1, Canada
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  • For correspondence: kmurphy@mcmaster.ca
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Abstract

A collection of glutamatergic and GABAergic proteins participate in regulating experience-dependent plasticity in the visual cortex (V1). Many studies have characterized changes to those proteins caused by monocular deprivation (MD) during the critical period (CP), but less is known about changes that occur when MD stops. We measured the effects of 3 types of visual experience after MD (n=24, 10 male and 14 female); reverse occlusion (RO), binocular deprivation (BD), or binocular vision, on the expression of synaptic proteins in V1 including glutamatergic and GABAergic receptor subunits. Synapsin expression was increased by RO but not affected by the other treatments. BD shifted the balance between glutamatergic and GABAergic receptor subunits to favor GABAAα1. In contrast, BV shifted expression to favor the glutamatergic mechanisms by increasing NMDAR and decreasing GABAAα1 subunits. None of the conditions returned normal expression levels to all of the proteins, but BV was the closest.

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Posted June 27, 2019.
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Recovery of glutamatergic and GABAergic protein expression in visual cortex after monocular deprivation
Justin L. Balsor, David G. Jones, Kathryn M. Murphy
bioRxiv 684191; doi: https://doi.org/10.1101/684191
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Recovery of glutamatergic and GABAergic protein expression in visual cortex after monocular deprivation
Justin L. Balsor, David G. Jones, Kathryn M. Murphy
bioRxiv 684191; doi: https://doi.org/10.1101/684191

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