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Computational design of anti-CRISPR proteins with improved inhibition potency and expanded specificity
Jan Mathony, Zander Harteveld, Carolin Schmelas, Julius Upmeier zu Belzen, Sabine Aschenbrenner, Mareike D. Hoffmann, Christina Stengl, Andreas Scheck, Stéphane Rosset, Dirk Grimm, Roland Eils, Bruno E. Correia, Dominik Niopek
doi: https://doi.org/10.1101/685032
Jan Mathony
1Synthetic Biology Group, Institute for Pharmacy and Molecular Biotechnology (IPMB) and Center for Quantitative Analysis of Molecular and Cellular Biosystems (BioQuant), University of Heidelberg, Heidelberg, 69120, Germany
Zander Harteveld
2Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, CH-1015, Switzerland and Swiss Institute of Bioinformatics (SIB), Lausanne, CH-1015, Switzerland
Carolin Schmelas
3Department of Infectious Diseases, Virology, University Hospital Heidelberg, Heidelberg, 69120, Germany
4BioQuant Center and Cluster of Excellence CellNetworks at Heidelberg University, Heidelberg, 69120, Germany
Julius Upmeier zu Belzen
1Synthetic Biology Group, Institute for Pharmacy and Molecular Biotechnology (IPMB) and Center for Quantitative Analysis of Molecular and Cellular Biosystems (BioQuant), University of Heidelberg, Heidelberg, 69120, Germany
5Digital Health Center, Berlin Institute of Health (BIH) and Charité, Berlin, 10178, Germany
6Health Data Science Unit, University Hospital Heidelberg, Heidelberg, 69120, Germany
Sabine Aschenbrenner
5Digital Health Center, Berlin Institute of Health (BIH) and Charité, Berlin, 10178, Germany
7Department of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany
Mareike D. Hoffmann
1Synthetic Biology Group, Institute for Pharmacy and Molecular Biotechnology (IPMB) and Center for Quantitative Analysis of Molecular and Cellular Biosystems (BioQuant), University of Heidelberg, Heidelberg, 69120, Germany
7Department of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany
Christina Stengl
1Synthetic Biology Group, Institute for Pharmacy and Molecular Biotechnology (IPMB) and Center for Quantitative Analysis of Molecular and Cellular Biosystems (BioQuant), University of Heidelberg, Heidelberg, 69120, Germany
Andreas Scheck
2Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, CH-1015, Switzerland and Swiss Institute of Bioinformatics (SIB), Lausanne, CH-1015, Switzerland
Stéphane Rosset
2Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, CH-1015, Switzerland and Swiss Institute of Bioinformatics (SIB), Lausanne, CH-1015, Switzerland
Dirk Grimm
3Department of Infectious Diseases, Virology, University Hospital Heidelberg, Heidelberg, 69120, Germany
4BioQuant Center and Cluster of Excellence CellNetworks at Heidelberg University, Heidelberg, 69120, Germany
8German Center for Infection Research (DZIF) and German Center for Cardiovascular Research (DZHK), partner site Heidelberg, Heidelberg, 69120, Germany
Roland Eils
5Digital Health Center, Berlin Institute of Health (BIH) and Charité, Berlin, 10178, Germany
6Health Data Science Unit, University Hospital Heidelberg, Heidelberg, 69120, Germany
Bruno E. Correia
2Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, CH-1015, Switzerland and Swiss Institute of Bioinformatics (SIB), Lausanne, CH-1015, Switzerland
Dominik Niopek
1Synthetic Biology Group, Institute for Pharmacy and Molecular Biotechnology (IPMB) and Center for Quantitative Analysis of Molecular and Cellular Biosystems (BioQuant), University of Heidelberg, Heidelberg, 69120, Germany
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Posted June 27, 2019.
Computational design of anti-CRISPR proteins with improved inhibition potency and expanded specificity
Jan Mathony, Zander Harteveld, Carolin Schmelas, Julius Upmeier zu Belzen, Sabine Aschenbrenner, Mareike D. Hoffmann, Christina Stengl, Andreas Scheck, Stéphane Rosset, Dirk Grimm, Roland Eils, Bruno E. Correia, Dominik Niopek
bioRxiv 685032; doi: https://doi.org/10.1101/685032
Computational design of anti-CRISPR proteins with improved inhibition potency and expanded specificity
Jan Mathony, Zander Harteveld, Carolin Schmelas, Julius Upmeier zu Belzen, Sabine Aschenbrenner, Mareike D. Hoffmann, Christina Stengl, Andreas Scheck, Stéphane Rosset, Dirk Grimm, Roland Eils, Bruno E. Correia, Dominik Niopek
bioRxiv 685032; doi: https://doi.org/10.1101/685032
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