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Small molecule inhibition of PIKFYVE kinase rescues gain- and loss-of-function C9ORF72 ALS/FTD disease processes in vivo
View ORCID ProfileK. A. Staats, C. Seah, A. Sahimi, Y. Wang, N. Koutsodendris, S. Lin, D. Kim, W-H. Chang, K. A. Gray, Y. Shi, Y. Li, M. Chateau, V. R. Vangoor, K. Senthilkumar, R. J. Pasterkamp, P. Cannon, B.V. Zlokovic, J. K. Ichida
doi: https://doi.org/10.1101/685800
K. A. Staats
1Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
C. Seah
1Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
A. Sahimi
1Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Y. Wang
2Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
N. Koutsodendris
1Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
S. Lin
1Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
D. Kim
1Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
W-H. Chang
1Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
K. A. Gray
1Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Y. Shi
1Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Y. Li
1Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
M. Chateau
3Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
V. R. Vangoor
4Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands
K. Senthilkumar
4Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands
R. J. Pasterkamp
4Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands
P. Cannon
3Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
B.V. Zlokovic
2Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
J. K. Ichida
1Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Article usage
Posted June 28, 2019.
Small molecule inhibition of PIKFYVE kinase rescues gain- and loss-of-function C9ORF72 ALS/FTD disease processes in vivo
K. A. Staats, C. Seah, A. Sahimi, Y. Wang, N. Koutsodendris, S. Lin, D. Kim, W-H. Chang, K. A. Gray, Y. Shi, Y. Li, M. Chateau, V. R. Vangoor, K. Senthilkumar, R. J. Pasterkamp, P. Cannon, B.V. Zlokovic, J. K. Ichida
bioRxiv 685800; doi: https://doi.org/10.1101/685800
Small molecule inhibition of PIKFYVE kinase rescues gain- and loss-of-function C9ORF72 ALS/FTD disease processes in vivo
K. A. Staats, C. Seah, A. Sahimi, Y. Wang, N. Koutsodendris, S. Lin, D. Kim, W-H. Chang, K. A. Gray, Y. Shi, Y. Li, M. Chateau, V. R. Vangoor, K. Senthilkumar, R. J. Pasterkamp, P. Cannon, B.V. Zlokovic, J. K. Ichida
bioRxiv 685800; doi: https://doi.org/10.1101/685800
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