Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Expansion of apical extracellular matrix underlies the morphogenesis of a recently evolved structure

View ORCID ProfileSarah Jacquelyn Smith, View ORCID ProfileLance A. Davidson, View ORCID ProfileMark Rebeiz
doi: https://doi.org/10.1101/686089
Sarah Jacquelyn Smith
1University of Pittsburgh Department of Biological Sciences, Pittsburgh, PA 15260, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Sarah Jacquelyn Smith
Lance A. Davidson
2University of Pittsburgh, Department of Bioengineering, Pittsburgh, PA 15260, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Lance A. Davidson
Mark Rebeiz
1University of Pittsburgh Department of Biological Sciences, Pittsburgh, PA 15260, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Mark Rebeiz
  • For correspondence: rebeiz@pitt.edu
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

One of the fundamental gaps in our knowledge of the evolution of novel structures is understanding how the morphogenetic processes that form these structures arise. Here, we traced the cellular development of a morphological novelty, the posterior lobe of D. melanogaster. We found that this genital outgrowth forms through an extreme increase in cell height. By examining the apical extracellular matrix (aECM), we uncovered a vast network associated with the developing genitalia of lobed and non-lobed species. We observed that cells which will form the posterior lobe show expanded expression of the aECM protein Dumpy which connects them to the ancestral aECM network. Further analysis demonstrated a required role for Dumpy in cell height increase during development. We propose that the aECM presents a rich reservoir for generating morphological novelty, in addition to highlighting a yet unseen role for aECM in regulating extreme cell height.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted June 28, 2019.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Expansion of apical extracellular matrix underlies the morphogenesis of a recently evolved structure
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Expansion of apical extracellular matrix underlies the morphogenesis of a recently evolved structure
Sarah Jacquelyn Smith, Lance A. Davidson, Mark Rebeiz
bioRxiv 686089; doi: https://doi.org/10.1101/686089
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Expansion of apical extracellular matrix underlies the morphogenesis of a recently evolved structure
Sarah Jacquelyn Smith, Lance A. Davidson, Mark Rebeiz
bioRxiv 686089; doi: https://doi.org/10.1101/686089

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Developmental Biology
Subject Areas
All Articles
  • Animal Behavior and Cognition (3609)
  • Biochemistry (7584)
  • Bioengineering (5533)
  • Bioinformatics (20816)
  • Biophysics (10341)
  • Cancer Biology (7992)
  • Cell Biology (11651)
  • Clinical Trials (138)
  • Developmental Biology (6616)
  • Ecology (10222)
  • Epidemiology (2065)
  • Evolutionary Biology (13639)
  • Genetics (9553)
  • Genomics (12856)
  • Immunology (7928)
  • Microbiology (19561)
  • Molecular Biology (7673)
  • Neuroscience (42165)
  • Paleontology (308)
  • Pathology (1259)
  • Pharmacology and Toxicology (2204)
  • Physiology (3271)
  • Plant Biology (7052)
  • Scientific Communication and Education (1294)
  • Synthetic Biology (1953)
  • Systems Biology (5431)
  • Zoology (1119)