Abstract
A typical feature of glioblastoma (GBM) growth is local recurrence after surgery. However, some GBMs recur distally. It has been noted that GBM patients with perioperative ischemia are more likely to have distal recurrence and that GBM cells migrate faster under hypoxic conditions. We apply the Proliferation Invasion Hypoxia Necrosis Angiogenesis (PIHNA) model to examine the effect of faster hypoxic cell migration on simulated GBM growth. Results suggest that a highly migratory hypoxic cell population drives the growth of the whole tumor and leads to distant recurrence, as do higher normoxic tumor cell migration and low cellular proliferation rates.
Competing Interest Statement
The authors have declared no competing interest.
Footnotes
Research supported by the National Institutes of Health Grant U54CA193489 (Moffitt PS-OC); School of Mathematical Sciences at the University of Nottingham, UK; and Mayo Clinic, Arizona.
(e-mail: curtin.lee{at}mayo.edu)
