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The shared neoantigen landscape of MSI cancers reflects immunoediting during tumor evolution
Alexej Ballhausen, Moritz Jakob Przybilla, Michael Jendrusch, View ORCID ProfileSaskia Haupt, Elisabeth Pfaffendorf, Markus Draxlbauer, Florian Seidler, Sonja Krausert, Aysel Ahadova, Martin Simon Kalteis, Daniel Heid, Johannes Gebert, Maria Bonsack, Sarah Schott, Hendrik Bläker, Toni Seppälä, Jukka-Pekka Mecklin, Sanne Ten Broeke, Maartje Nielsen, Vincent Heuveline, Julia Krzykalla, Axel Benner, Angelika Beate Riemer, Magnus von Knebel Doeberitz, Matthias Kloor
doi: https://doi.org/10.1101/691469
Alexej Ballhausen
1Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
2Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany
3Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL Heidelberg, Germany
Moritz Jakob Przybilla
1Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
2Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany
3Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL Heidelberg, Germany
Michael Jendrusch
1Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
2Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany
3Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL Heidelberg, Germany
Saskia Haupt
4Engineering Mathematics and Computing Lab (EMCL), Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University, Heidelberg, Germany
Elisabeth Pfaffendorf
1Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
2Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany
3Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL Heidelberg, Germany
Markus Draxlbauer
1Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
2Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany
3Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL Heidelberg, Germany
Florian Seidler
1Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
2Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany
3Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL Heidelberg, Germany
Sonja Krausert
1Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
2Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany
3Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL Heidelberg, Germany
Aysel Ahadova
1Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
2Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany
3Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL Heidelberg, Germany
Martin Simon Kalteis
1Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
2Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany
3Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL Heidelberg, Germany
Daniel Heid
1Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
2Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany
3Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL Heidelberg, Germany
Johannes Gebert
1Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
2Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany
3Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL Heidelberg, Germany
Maria Bonsack
5Immunotherapy and Immunoprevention, German Cancer Research Center (DKFZ), Heidelberg, Germany
6Molecular Vaccine Design, German Center for Infection Research (DZIF), partner site Heidelberg, Heidelberg, Germany
7Faculty of Biosciences, Heidelberg University, Heidelberg, Germany
Sarah Schott
8Department of Obstetrics and Gynecology, University Hospital Heidelberg, Heidelberg, Germany
Hendrik Bläker
9Institute of Pathology, University Hospital Leipzig, Leipzig, Germany
Toni Seppälä
10Department of Gastrointestinal Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
Jukka-Pekka Mecklin
11Department of Education and Research, Central Finland Central Hospital, Jyväskylä, Finland, and Sports and Health Sciences, University of Jyväskylä, Jyväskylä, Finland
Sanne Ten Broeke
12Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
Maartje Nielsen
12Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
Vincent Heuveline
4Engineering Mathematics and Computing Lab (EMCL), Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University, Heidelberg, Germany
Julia Krzykalla
13Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany
Axel Benner
13Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany
Angelika Beate Riemer
5Immunotherapy and Immunoprevention, German Cancer Research Center (DKFZ), Heidelberg, Germany
6Molecular Vaccine Design, German Center for Infection Research (DZIF), partner site Heidelberg, Heidelberg, Germany
Magnus von Knebel Doeberitz
1Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
2Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany
3Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL Heidelberg, Germany
Matthias Kloor
1Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
2Collaboration Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany
3Molecular Medicine Partnership Unit (MMPU), Heidelberg University Hospital and EMBL Heidelberg, Germany
Posted July 16, 2019.
The shared neoantigen landscape of MSI cancers reflects immunoediting during tumor evolution
Alexej Ballhausen, Moritz Jakob Przybilla, Michael Jendrusch, Saskia Haupt, Elisabeth Pfaffendorf, Markus Draxlbauer, Florian Seidler, Sonja Krausert, Aysel Ahadova, Martin Simon Kalteis, Daniel Heid, Johannes Gebert, Maria Bonsack, Sarah Schott, Hendrik Bläker, Toni Seppälä, Jukka-Pekka Mecklin, Sanne Ten Broeke, Maartje Nielsen, Vincent Heuveline, Julia Krzykalla, Axel Benner, Angelika Beate Riemer, Magnus von Knebel Doeberitz, Matthias Kloor
bioRxiv 691469; doi: https://doi.org/10.1101/691469
The shared neoantigen landscape of MSI cancers reflects immunoediting during tumor evolution
Alexej Ballhausen, Moritz Jakob Przybilla, Michael Jendrusch, Saskia Haupt, Elisabeth Pfaffendorf, Markus Draxlbauer, Florian Seidler, Sonja Krausert, Aysel Ahadova, Martin Simon Kalteis, Daniel Heid, Johannes Gebert, Maria Bonsack, Sarah Schott, Hendrik Bläker, Toni Seppälä, Jukka-Pekka Mecklin, Sanne Ten Broeke, Maartje Nielsen, Vincent Heuveline, Julia Krzykalla, Axel Benner, Angelika Beate Riemer, Magnus von Knebel Doeberitz, Matthias Kloor
bioRxiv 691469; doi: https://doi.org/10.1101/691469
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