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HERV-K and HERV-W transcriptional activity in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome

Lucas S Rodrigues, Luiz H da Silva Nali, Cibele O D Leal, Ester C Sabino, Eliana M Lacerda, Caroline C Kingdon, Luis Nacul, View ORCID ProfileCamila M Romano
doi: https://doi.org/10.1101/693465
Lucas S Rodrigues
1Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil
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Luiz H da Silva Nali
1Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil
2Universidade Santo Amaro, Pós-Graduação em Ciências da Saúde
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Cibele O D Leal
1Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil
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Ester C Sabino
1Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil
3Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Eliana M Lacerda
4Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
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Caroline C Kingdon
4Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
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Luis Nacul
4Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
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Camila M Romano
1Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil
5Hospital das Clinicas HCFMUSP (LIM52), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
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  • ORCID record for Camila M Romano
  • For correspondence: cmromano@usp.br
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Abstract

Chronic Fatigue Syndrome / Myalgic Encephalomyelitis (CFS / MS) is an incapacitating chronic disease that dramatically compromise the life quality. The CFS/ME pathogenesis is multifactorial, and it is believed that immunological, metabolic and environmental factors play a role. It is well documented an increased activity of Human endogenous retroviruses (HERVs) from different families in autoimmune and neurological diseases, making these elements good candidates for biomarkers or even triggers for such diseases. Here the expression of Endogenous retroviruses K and W (HERV–K and HERV–W) was determined in blood from moderately and severely affected ME/CFS patients. HERV-K was overexpressed only in moderately affected individuals and HERV-W showed no difference. This is the first report about HERV-K differential expression in moderate ME/CFS.

Footnotes

  • Methods were updated for clarify the patients classification: Participants with ME/CFS were defined as moderate or severely affected based on their mobility: those described as severely affected were house-bound or bed-bound, while those described as having mild/moderate ME/CFS were ambulatory [11]. Discussion item was updated to include a new relevant reference: Recently, it was suggested that differential methylation patterns of promoters in ME/CFS would impact on the expression of nearby transposable elements, including HERVs [19]. The following reference was added 19. Almenar-Perez E, Ovejero T, Sanchez-Fito T, Espejo JA, Nathanson L, Oltra E. Epigenetic Components of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Uncover Potential Transposable Element Activation. Clin Ther. 2019;41(4):675-698.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted October 24, 2019.
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HERV-K and HERV-W transcriptional activity in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome
Lucas S Rodrigues, Luiz H da Silva Nali, Cibele O D Leal, Ester C Sabino, Eliana M Lacerda, Caroline C Kingdon, Luis Nacul, Camila M Romano
bioRxiv 693465; doi: https://doi.org/10.1101/693465
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HERV-K and HERV-W transcriptional activity in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome
Lucas S Rodrigues, Luiz H da Silva Nali, Cibele O D Leal, Ester C Sabino, Eliana M Lacerda, Caroline C Kingdon, Luis Nacul, Camila M Romano
bioRxiv 693465; doi: https://doi.org/10.1101/693465

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