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- July 19, 2019.
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Author Information
- Kerry Barkan1,
- Panagiotis Lagarias2,
- Eleni Vrontaki2,
- Dimitrios Stamatis2,
- Sam Hoare3,
- Karl-Norbert Klotz4,
- Antonios Kolocouris2,* and
- Graham Ladds1,*
- 1Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK
- 2Section of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, Athens, 15771, Greece
- 3Pharmechanics LLC, 14 Sunnyside Drive South, Owego, NY 13827, USA
- 4Institute of Pharmacology and Toxicology, University of Würzburg, Versbacher Str. 9 97078 Würzburg, Germany
- ↵*Address for correspondence:
Dr Graham Ladds, Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD Tel; +44 (0) 1223 334020. Email: grl30{at}cam.ac.uk.; Dr Antonios Kolocouris, Department of Medicinal Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, Athens, 15 771. Tel: 210-727-4834, Email: ankol{at}pharm.uoa.gr.
Author Contributions: KB, AK and GL conceived and designed the research; KB performed the mammalian assays; KK conducted radioligand binding experiments, PL, DS, EV and AK performed the molecular dynamic simulations; SH derived the equations for the ‘Rapid competitor dissociation kinetics’ model; KB, GL and AK analysed data; KB and GL wrote manuscript, AK revised and edited the manuscript.