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Genetic paths to evolutionary rescue and the distribution of fitness effects along them

Matthew M Osmond, View ORCID ProfileSarah P Otto, View ORCID ProfileGuillaume Martin
doi: https://doi.org/10.1101/696260
Matthew M Osmond
∗Biodiversity Centre & Department of Zoology, University of British Columbia
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  • For correspondence: mmosmond@gmail.com
Sarah P Otto
∗Biodiversity Centre & Department of Zoology, University of British Columbia
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Guillaume Martin
†Institut des Sciences de l’Evolution de Montpellier, Université Montpellier II
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  • ORCID record for Guillaume Martin
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ABSTRACT

The past century has seen substantial theoretical and empirical progress on the genetic basis of adaptation. Over this same period a pressing need to prevent the evolution of drug resistance has uncovered much about the potential genetic basis of persistence in declining populations. However, we have little theory to predict and generalize how persistence – by sufficiently rapid adaptation – might be realized in this explicitly demographic scenario. Here we use Fisher’s geometric model with absolute fitness to begin a line of theoretical inquiry into the genetic basis of evolutionary rescue, focusing here on asexual populations that adapt through de novo mutations. We show how the dominant genetic path to rescue switches from a single mutation to multiple as mutation rates and the severity of the environmental change increase. In multi-step rescue, intermediate genotypes that themselves go extinct provide a ‘springboard’ to rescue genotypes. Comparing to a scenario where persistence is assured, our approach allows us to quantify how a race between evolution and extinction leads to a genetic basis of adaptation that is composed of fewer loci of larger effect. We hope this work brings awareness to the impact of demography on the genetic basis of adaptation.

Footnotes

  • Discuss FGM parameters and kurtosis, and clarify throughout.

  • https://github.com/mmosmond/GeneticBasisOfRescue

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted November 10, 2019.
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Genetic paths to evolutionary rescue and the distribution of fitness effects along them
Matthew M Osmond, Sarah P Otto, Guillaume Martin
bioRxiv 696260; doi: https://doi.org/10.1101/696260
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Genetic paths to evolutionary rescue and the distribution of fitness effects along them
Matthew M Osmond, Sarah P Otto, Guillaume Martin
bioRxiv 696260; doi: https://doi.org/10.1101/696260

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