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The Genome of the Zebra Mussel, Dreissena polymorpha: A Resource for Invasive Species Research

Michael A. McCartney, View ORCID ProfileBenjamin Auch, View ORCID ProfileThomas Kono, View ORCID ProfileSophie Mallez, View ORCID ProfileYing Zhang, Angelico Obille, Aaron Becker, View ORCID ProfileJuan E. Abrahante, John Garbe, View ORCID ProfileJonathan P. Badalamenti, Adam Herman, Hayley Mangelson, Ivan Liachko, Shawn Sullivan, View ORCID ProfileEli D. Sone, Sergey Koren, View ORCID ProfileKevin A. T. Silverstein, View ORCID ProfileKenneth B. Beckman, View ORCID ProfileDaryl M. Gohl
doi: https://doi.org/10.1101/696732
Michael A. McCartney
1University of Minnesota, Minnesota Aquatic Invasive Species Research Center and Dept. of Fisheries, Wildlife and Conservation Biology, St. Paul, MN, USA
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  • For correspondence: mccartneymichael324@gmail.com dmgohl@umn.edu
Benjamin Auch
2University of Minnesota Genomics Center, Minneapolis, MN, USA
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Thomas Kono
3Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN, USA
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Sophie Mallez
1University of Minnesota, Minnesota Aquatic Invasive Species Research Center and Dept. of Fisheries, Wildlife and Conservation Biology, St. Paul, MN, USA
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Ying Zhang
3Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN, USA
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Angelico Obille
4Institute of Biomaterials & Biomedical Engineering, University of Toronto, Toronto, ON, Canada
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Aaron Becker
2University of Minnesota Genomics Center, Minneapolis, MN, USA
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Juan E. Abrahante
5University of Minnesota Informatics Institute, Minneapolis, MN, USA
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John Garbe
2University of Minnesota Genomics Center, Minneapolis, MN, USA
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Jonathan P. Badalamenti
2University of Minnesota Genomics Center, Minneapolis, MN, USA
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Adam Herman
3Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN, USA
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Hayley Mangelson
6Phase Genomics, Seattle, WA, USA
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Ivan Liachko
6Phase Genomics, Seattle, WA, USA
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Shawn Sullivan
6Phase Genomics, Seattle, WA, USA
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Eli D. Sone
4Institute of Biomaterials & Biomedical Engineering, University of Toronto, Toronto, ON, Canada
7Department of Materials Science & Engineering, University of Toronto, Toronto, ON, Canada
8Faculty of Dentistry, University of Toronto, Toronto, ON, Canada
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Sergey Koren
9Genome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, Bethesda, Maryland, USA
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Kevin A. T. Silverstein
3Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN, USA
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Kenneth B. Beckman
2University of Minnesota Genomics Center, Minneapolis, MN, USA
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Daryl M. Gohl
2University of Minnesota Genomics Center, Minneapolis, MN, USA
10Department of Genetics, Cell Biology, and Developmental Biology, University of Minnesota, Minneapolis, MN, USA
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  • For correspondence: mccartneymichael324@gmail.com dmgohl@umn.edu
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Abstract

The zebra mussel, Dreissena polymorpha, continues to spread from its native range in Eurasia to Europe and North America, causing billions of dollars in damage and dramatically altering invaded aquatic ecosystems. Despite these impacts, there are few genomic resources for Dreissena or related bivalves, with nearly 450 million years of divergence between zebra mussels and its closest sequenced relative. Although the D. polymorpha genome is highly repetitive, we have used a combination of long-read sequencing and Hi-C-based scaffolding to generate the highest quality molluscan assembly to date. Through comparative analysis and transcriptomics experiments we have gained insights into processes that likely control the invasive success of zebra mussels, including shell formation, synthesis of byssal threads, and thermal tolerance. We identified multiple intact Steamer-Like Elements, a retrotransposon that has been linked to transmissible cancer in marine clams. We also found that D. polymorpha have an unusual 67 kb mitochondrial genome containing numerous tandem repeats, making it the largest observed in Eumetazoa. Together these findings create a rich resource for invasive species research and control efforts.

Footnotes

  • https://zebra_mussel.s3.msi.umn.edu/Dpolymorpha_Assembly.V2.Final_wMito.fasta.gz

  • https://zebra_mussel.s3.msi.umn.edu/Dpolymorpha_Assembly.V2.Final_wMito.gff3.gz

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted July 09, 2019.
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The Genome of the Zebra Mussel, Dreissena polymorpha: A Resource for Invasive Species Research
Michael A. McCartney, Benjamin Auch, Thomas Kono, Sophie Mallez, Ying Zhang, Angelico Obille, Aaron Becker, Juan E. Abrahante, John Garbe, Jonathan P. Badalamenti, Adam Herman, Hayley Mangelson, Ivan Liachko, Shawn Sullivan, Eli D. Sone, Sergey Koren, Kevin A. T. Silverstein, Kenneth B. Beckman, Daryl M. Gohl
bioRxiv 696732; doi: https://doi.org/10.1101/696732
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The Genome of the Zebra Mussel, Dreissena polymorpha: A Resource for Invasive Species Research
Michael A. McCartney, Benjamin Auch, Thomas Kono, Sophie Mallez, Ying Zhang, Angelico Obille, Aaron Becker, Juan E. Abrahante, John Garbe, Jonathan P. Badalamenti, Adam Herman, Hayley Mangelson, Ivan Liachko, Shawn Sullivan, Eli D. Sone, Sergey Koren, Kevin A. T. Silverstein, Kenneth B. Beckman, Daryl M. Gohl
bioRxiv 696732; doi: https://doi.org/10.1101/696732

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