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Estimates of genetic load in small populations suggest extensive purging of deleterious alleles

View ORCID ProfileTom van der Valk, Marc de Manuel, Tomas Marques-Bonet, Katerina Guschanski
doi: https://doi.org/10.1101/696831
Tom van der Valk
1Department of Ecology and Genetics, Animal Ecology, Evolutionary Biology Centre, Uppsala University, Norbyvägen 18D, 752 36, Uppsala, Sweden
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  • ORCID record for Tom van der Valk
  • For correspondence: tom.vandervalk@ebc.uu.se katerina.guschanski@ebc.uu.se
Marc de Manuel
2Institute of Evolutionary Biology (UPF-CSIC), PRBB, Dr. Aiguader 88, 08003 Barcelona, Spain
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Tomas Marques-Bonet
2Institute of Evolutionary Biology (UPF-CSIC), PRBB, Dr. Aiguader 88, 08003 Barcelona, Spain
3Catalan Institution of Research and Advanced Studies (ICREA), Passeig de Lluís Companys, 23, 08010, Barcelona, Spain
4CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain
5Institut Català de Paleontologia Miquel Crusafont, Universitat Autònoma de Barcelona, Edifici ICTA-ICP, c/ Columnes s/n, 08193 Cerdanyola del Vallès, Barcelona, Spain
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Katerina Guschanski
1Department of Ecology and Genetics, Animal Ecology, Evolutionary Biology Centre, Uppsala University, Norbyvägen 18D, 752 36, Uppsala, Sweden
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  • For correspondence: tom.vandervalk@ebc.uu.se katerina.guschanski@ebc.uu.se
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Article Information

doi 
https://doi.org/10.1101/696831
History 
  • July 9, 2019.

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  • You are currently viewing Version 1 of this article (July 9, 2019 - 07:32).
  • View Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Tom van der Valk1,*,
  2. Marc de Manuel2,
  3. Tomas Marques-Bonet2,3,4,5 and
  4. Katerina Guschanski1,*
  1. 1Department of Ecology and Genetics, Animal Ecology, Evolutionary Biology Centre, Uppsala University, Norbyvägen 18D, 752 36, Uppsala, Sweden
  2. 2Institute of Evolutionary Biology (UPF-CSIC), PRBB, Dr. Aiguader 88, 08003 Barcelona, Spain
  3. 3Catalan Institution of Research and Advanced Studies (ICREA), Passeig de Lluís Companys, 23, 08010, Barcelona, Spain
  4. 4CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain
  5. 5Institut Català de Paleontologia Miquel Crusafont, Universitat Autònoma de Barcelona, Edifici ICTA-ICP, c/ Columnes s/n, 08193 Cerdanyola del Vallès, Barcelona, Spain
  1. ↵*Corresponding authors: tom.vandervalk{at}ebc.uu.se (T.v.d.V.); katerina.guschanski{at}ebc.uu.se (K.G.)
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Posted July 09, 2019.
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Estimates of genetic load in small populations suggest extensive purging of deleterious alleles
Tom van der Valk, Marc de Manuel, Tomas Marques-Bonet, Katerina Guschanski
bioRxiv 696831; doi: https://doi.org/10.1101/696831
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Estimates of genetic load in small populations suggest extensive purging of deleterious alleles
Tom van der Valk, Marc de Manuel, Tomas Marques-Bonet, Katerina Guschanski
bioRxiv 696831; doi: https://doi.org/10.1101/696831

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