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Multiple timescales account for adaptive responses across sensory cortices

View ORCID ProfileKenneth W. Latimer, Dylan Barbera, Michael Sokoletsky, Bshara Awwad, Yonaton Katz, Israel Nelken, Ilan Lampl, Adrienne Fairhall, Nicholas J. Priebe
doi: https://doi.org/10.1101/700062
Kenneth W. Latimer
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Dylan Barbera
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Michael Sokoletsky
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Bshara Awwad
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Yonaton Katz
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Israel Nelken
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  • For correspondence: nico@austin.utexas.edu
Ilan Lampl
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  • For correspondence: nico@austin.utexas.edu
Adrienne Fairhall
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  • For correspondence: nico@austin.utexas.edu
Nicholas J. Priebe
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  • For correspondence: nico@austin.utexas.edu
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Abstract

Sensory systems encounter remarkably diverse stimuli in the external environment. Natural stimuli exhibit timescales and amplitudes of variation that span a wide range. Mechanisms of adaptation, ubiquitous feature of sensory systems, allow for the accommodation of this range of scales. Are there common rules of adaptation across different sensory modalities? We measured the membrane potential responses of individual neurons in the visual, somatosensory and auditory cortices to discrete, punctate stimuli delivered at a wide range of fixed and nonfixed frequencies. We find that the adaptive profile of the response is largely preserved across these three areas, exhibiting attenuation and responses to the cessation of stimulation which are signatures of response to changes in stimulus statistics. We demonstrate that these adaptive responses can emerge from a simple model based on the integration of fixed filters operating over multiple time scales.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted July 14, 2019.
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Multiple timescales account for adaptive responses across sensory cortices
Kenneth W. Latimer, Dylan Barbera, Michael Sokoletsky, Bshara Awwad, Yonaton Katz, Israel Nelken, Ilan Lampl, Adrienne Fairhall, Nicholas J. Priebe
bioRxiv 700062; doi: https://doi.org/10.1101/700062
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Multiple timescales account for adaptive responses across sensory cortices
Kenneth W. Latimer, Dylan Barbera, Michael Sokoletsky, Bshara Awwad, Yonaton Katz, Israel Nelken, Ilan Lampl, Adrienne Fairhall, Nicholas J. Priebe
bioRxiv 700062; doi: https://doi.org/10.1101/700062

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