The CIViC knowledge model and standard operating procedures for curation and clinical interpretation of variants in cancer

Arpad M. Danos; Kilannin Krysiak; Erica K. Barnell; Adam C. Coffman; Joshua F. McMichael; Susanna Kiwala; Nicholas C. Spies; Lana M. Sheta; Shahil P. Pema; Lynzey Kujan; Kaitlin A. Clark; Amber Z. Wollam; Shruti Rao; Deborah I. Ritter; Dmitriy Sonkin; Gordana Raca; Raymond H. Kim; Alex H. Wagner; Subha Madhavan; Malachi Griffith; Obi L. Griffith

doi:10.1101/700179

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The CIViC knowledge model and standard operating procedures for curation and clinical interpretation of variants in cancer

View ORCID ProfileArpad M. Danos, View ORCID ProfileKilannin Krysiak, View ORCID ProfileErica K. Barnell, Adam C. Coffman, Joshua F. McMichael, View ORCID ProfileSusanna Kiwala, View ORCID ProfileNicholas C. Spies, View ORCID ProfileLana M. Sheta, View ORCID ProfileShahil P. Pema, View ORCID ProfileLynzey Kujan, Kaitlin A. Clark, View ORCID ProfileAmber Z. Wollam, View ORCID ProfileShruti Rao, Deborah I. Ritter, View ORCID ProfileDmitriy Sonkin, View ORCID ProfileGordana Raca, Raymond H. Kim, View ORCID ProfileAlex H. Wagner, View ORCID ProfileSubha Madhavan, View ORCID ProfileMalachi Griffith, View ORCID ProfileObi L. Griffith

doi: https://doi.org/10.1101/700179

Arpad M. Danos

1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA

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Kilannin Krysiak

1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA

2Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA

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Erica K. Barnell

1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA

3Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA

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Adam C. Coffman

1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA

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Joshua F. McMichael

1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA

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Susanna Kiwala

1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA

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Nicholas C. Spies

1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA

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Lana M. Sheta

1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA

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Shahil P. Pema

1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA

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Lynzey Kujan

1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA

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Kaitlin A. Clark

1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA

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Amber Z. Wollam

1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA

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Shruti Rao

4Innovation Center for Biomedical Informatics, Georgetown University, Washington D.C., USA

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Deborah I. Ritter

5Department of Pediatrics, Texas Children’s Hospital, Baylor College of Medicine, Houston, Texas, USA

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Dmitriy Sonkin

6Biometric Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, Maryland, USA

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Gordana Raca

7Keck School of Medicine, University of Southern California, Los Angeles, California, USA

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Raymond H. Kim

8Fred A. Litwin Family Center in Genetic Medicine, University Health Network, Toronto, ON, Canada

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Alex H. Wagner

1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA

2Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA

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Subha Madhavan

4Innovation Center for Biomedical Informatics, Georgetown University, Washington D.C., USA

9Georgetown Lombardi Comprehensive Cancer Center, Washington, District of Columbia, USA

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Malachi Griffith

1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA

2Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA

3Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA

10Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA

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For correspondence: mgriffit@wustl.edu obigriffith@wustl.edu

Obi L. Griffith

1McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA

2Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA

3Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA

10Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA

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For correspondence: mgriffit@wustl.edu obigriffith@wustl.edu

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Posted July 14, 2019.

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The CIViC knowledge model and standard operating procedures for curation and clinical interpretation of variants in cancer

Arpad M. Danos, Kilannin Krysiak, Erica K. Barnell, Adam C. Coffman, Joshua F. McMichael, Susanna Kiwala, Nicholas C. Spies, Lana M. Sheta, Shahil P. Pema, Lynzey Kujan, Kaitlin A. Clark, Amber Z. Wollam, Shruti Rao, Deborah I. Ritter, Dmitriy Sonkin, Gordana Raca, Raymond H. Kim, Alex H. Wagner, Subha Madhavan, Malachi Griffith, Obi L. Griffith

bioRxiv 700179; doi: https://doi.org/10.1101/700179

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